目的：运用时域分析方法分析比较高血压病弦脉和非高血压病弦脉的脉象参数信息，初步推断两类弦脉的血流动力学改变及形成机理。方法：应用ZBOX-1型中医脉象仪采集224例原发性高血压病患者的压力脉图和300例非高血压病弦脉压力脉图，比较高血压病弦脉与非高血压病弦脉脉图对应的时域参数（h3/h1、h4/h1、w/t）的特点。结果：高血压病弦脉组、非高血压病弦脉组脉图h3/h1值均显著高于健康对照组（P <0.01），而高血压病弦脉组h3/h1值又显著高于非高血压病弦脉组（P <0.01）；高血压病弦脉组脉图h4/h1值显著高于正常组及非高血压病弦脉组（P <0.01）；高血压病弦脉组和非高血压病弦脉组脉图w/t值显著高于健康对照组（P <0.01）。结论：高血压病弦脉组外周阻力高、血管弹性差、大动脉的张力增高；而非高血压病弦脉组外周阻力无明显变化，但动脉顺应性减退、大动脉处于高压力、高张力的状态，两者具有不同的血流动力学基础。

This study was aimed to analyze pulse with time-domain analysis method in the comparison of string-like pulse figure parameters between hypertension and non-hypertension cases. The hemodynamics changes and formation mechanism between two kinds of string-like pulses were also initially inferred. The string-like pulse figure of 224 primary hypertension cases and 300 non-hypertension cases were collected and compared with the ZBOX-1 Pulse Condition Instrument. The time-domain parameters (h3/h1, h4/h1, w/t) were compared for hypertension string-like pulse and non-hypertension string-like pulse. The result showed that the h3/h1 value of string-like pulse of both hypertension and non-hypertension group is significantly higher than the healthy group (P<0.01); and the h3/h1 value of hypertension group is significantly higher than non-hypertension group (P<0.01); the h4/h1 value of hypertension group is significantly higher than non-hypertension and healthy groups (P<0.01); the w/t value of both hypertension and non-hypertension group are significantly higher than the healthy group ( P<0.01). It was concluded that the string-like pulse group of hypertension has high peripheral resistance, poor blood vessel elasticity and increased arterial tension. The string-like pulse group of non-hypertension has no significant changes in peripheral resistance. But the arterial compliance in non-hypertension group has been decreased. The main arteries are at high pressure and high tension status. Both of them have different blood dynamics basis.

科学技术部国家“十一五”科技支撑计划项目（2006BAI08B01-04）：中医四诊信息规范采集和融合方法研究，负责人：王忆勤；上海中医药大学上海市重点学科（第三期）经费资助（S30302）：上海中医药大学中医诊断学，负责人：王忆勤；浦东新区中医药事业发展专项资金项目（PZX2010-1）：中医舌面、脉诊检测仪器的研发及应用，负责人：王忆勤；上海市自然科学基金（11ZR1436600）：基于中医脉象特征分析的高血压病患者血管弹性功能评价研究，负责人：燕海霞。