中医认为，AD发病的关键是肾精虚损为本，导致痰瘀闭窍，临床上以补肾益气、活血解毒中药组成小复方取得较好的疗效。本文以多种动物模型观察防治老年性痴呆（AD）中药小复方的药理作用，并以药物工艺制备与药效评价相结合，确定中药小复方的组成与制备工艺。其中基础研究根据AD复杂的发病机制，应用体现AD病理生理特点的现代医学指标，以不同工艺制备的中药小复方，应用多种AD动物模型对其药效学作用进行评价，以期形成一个基于多种动物模型且能较全面反映AD特点及病理机制安全有效的中药小复方。

In the theory of traditional Chinese medicine (TCM), the key pathogenesis of Alzheimer's disease (AD) was kidney-essence deficiency, and then resulted in phlegm-stasis. So in clinical practice, concise prescriptions consisting herbs, which reinforce kidney qi, activate blood circulation and detoxicate, have good effect on the AD treatment. Based on various kinds of animal models, this paper discussed the pharmacological effects of concise prescriptions of Chinese medicine for AD prevention and treatment. The preparation technology and composition of concise prescriptions of Chinese medicine were determined based on the combination of Chinese medicine preparation technology and efficacy evaluation of the drugs. According to the complex pathogenesis of AD, we developed basic research method using concise prescriptions prepared by different technology and various animal models of AD. Changes of some advanced indicators were observed to reflect the pathological and physiological characteristics of AD and the pharmacodynamic effects of prescriptions. The formation of a safe and effective concise prescription is able to comprehensively reflect the pathogenesis and characteristics of AD based on various kinds of animal models.

科学技术部国家“重大新药创制”科技重大专项（2009ZX09103-391）：基于“虚-瘀-浊-毒”中医理论治疗认知障碍中药组分新配方-还脑益聪方的研究与开发，负责人：李浩；国家自然科学基金项目（30873338）：基于“虚-瘀-浊-毒”病机基础的配伍中药对APP转基因小鼠痴呆模型早期干预研究，负责人：李浩。