目的：探讨肾虚证候相关的中医和西医疾病谱。方法：通过主题词途径扩展检索1991~2010年间的肾虚专题研究文献，析出中医类和西医类疾病高频主题词，建立词篇矩阵和共现矩阵。利用SPSS和NetDraw等软件进行聚类和可视化处理，分析与肾虚证候相关的疾病分布。结果：检索获得肾虚证候相关研究文献2230篇，抽取主题词2172个，出现14128次。聚类和可视化结果显示，肾虚证候与不孕不育、阳萎、更年期综合症、腰痛、哮喘、月经失调、遗尿、痹证、崩漏、功血等中医病症关系密切；与不孕不育、骨质疏松、糖尿病、贫血、肾衰、肾炎、哮喘、高血压、前列腺炎、骨关节炎等西医疾病存在密切联系。结论：依据文献共词分析结果，显示出肾虚证候所涉及的中西医疾病谱，并从文献计量学角度探讨了肾虚证候与中医和西医疾病的联系程度。

This study was aimed to investigate the spectrum of diseases related to kidney deficiency. Articles on kidney deficiency published from 1991 to 2010 were collected from the CBM online. Medical subject headings (MeSH) were extracted and calculated with BICOMB. The co-occurrence matrix was built. The SPSS and NetDraw were applied to the analysis of the high-frequency MeSH on related diseases. The results showed that kidney deficiency have a close relationship with diseases in traditional Chinese medicine (TCM), such as infertility, impotence, climacteric syndrome, asthma, uterine bleeding, enuresis, menstrual disorder, amenorrhea, and etc. The kidney deficiency is also closely related to diseases in modern medicine, such as infertility, osteoporosis, diabetes mellitus, anemia, chronic renal failure, asthma, hypertension, nephritis, and etc. The spectrum of diseases related to kidney deficiency is concluded in both TCM and modern medicine. The relationship of kidney deficiency and spectrum of disease in both TCM and modern medicine has been revealed through bibliometrics.

科学技术部国家重点基础研究发展计划（“973计划”）（2010CB530401）：“肾藏精”理论文献与临床信息综合分析研究，负责人：郑洪新。