目的：评价腹泻型肠易激综合征（D-IBS）患者生存质量状态，并分析其影响因素。方法：采用肠易激综合征专用生存质量量表（IBS-QOL）对符合罗马芋标准的68 例D-IBS患者进行生存质量测评，并与健康体检者对比，分布从性别、年龄、文化程度、病程、症状严重度、焦虑抑郁状态6个因素分析对生存质量的影响。结果：68例D-IBS患者生存质量8个维度的评分均低于健康体检者（P<0.01），特别是在挑食、健康忧虑、焦虑不安、行为障碍方面较正常人明显下降；男女之间无明显差异（P>0.05）；除行为障碍、性行为、人际关系方面（P<0.05）外，各年龄组间无明显差异（P>0.05）；不同文化程度患者之间存在差异（P<0.05）；不同病程时间之间无明显差异（P>0.05）；不同症状严重度之间存在显著差异（P<0.01）；不同焦虑状态患者之间存在差异（P<0.01），除健康忧虑方面（P>0.05），不同抑郁状态患者之间存在差异（P<0.05）；在行为障碍、挑食、社会功能及总体得分方面，不同情绪异常状态患者之间存在差异（P<0.05）。性别、病程与生存质量总分之间无相关关系；年龄、症状严重度、焦虑、抑郁亚表积分与生存质量总分之间存在负相关关系；文化程度与生存质量总分之间存在正相关关系。结论：D-IBS患者总体生存质量水平较健康人群降低。影响其生存质量的明显因素有文化程度、症状严重度、心理因素；性别、年龄因素对IBS 生存质量的影响存在争议，病程并不影响患者生存质量。

This study was aimed to investigate the quality of life (QOL) in diarrhea-irritable bowel syndrome (D-IBS) patients and its influence factors. The Irritable Bowel Syndrome Specific Quality of Life Scale (IBS-QOL) was used in the QOL evaluation among 68 patients. Then, healthy subjects were compared with, from anxious (DY), conduct disorder (IN), body concept (Bl), health worries (HW), picky (FA), social function (SR), sex (Sx) and interpersonal (RL). The QOL was analyzed from six factors, including sex, age, education, disease duration, severity of symptoms, anxiety and depression. The results of IBS-QOL scores showed that eight directions, especially in FA, HW, DY, IN, among IBS patients were significantly lower than those in healthy people (P < 0.01). There was no significant difference between male and female (P > 0.05). Except RL, there are no significant differences in each age group (P > 0.05). Patients with different educational level have different point (P < 0.05). There was no significant difference between disease duration (P > 0.05). There was significant difference in the symptom severity (P < 0.01). Patients with different anxiety and patients with depression both have different point on QOL (P < 0.01). In IN, Bl, FA, SR, anxiety and depression in patients with integral low-exist. Gender and disease duration have no correlation to the total score of QOL. There are negative correlation between the age, symptom severity, anxiety scale scores, depression scale scores and QOL. Education level and QOL were positively correlated. It was concluded that QOL decreases in D-IBS patients. The main influence factors are educational level, severity of symptoms and mental status. The influence of sex and age to IBS-QOL is still in dispute. The disease duration does not affect the QOL of patients.

科学技术部国家重点基础研究发展计划（“973 计划”）项目（2009CB522705）：基于炎症性肠病肺支气管病损的肺与大肠表里关系研究，负责人：王新月。