目的：应用红外光谱法对蒙药并头黄芩原药材及不同溶剂提取物进行整体成分分析。方法：采用红外光谱、二阶导数红外光谱以及二维相关红外光谱，对蒙药并头黄芩药材及不同溶剂提取物（依次采用石油醚、乙醇、水提取）的化学成分的变化规律进行了研究。结果：在并头黄芩原药材中有明显的黄酮类化合物和糖类物质的红外特征吸收峰，说明该药材中主要含有黄酮类和多糖类成分。并头黄芩乙醇和水提取物的红外光谱图与原药材比较相似，说明其中所含的主要为黄酮类和多糖类成分。石油醚提取物的红外光谱与其它提取物谱图相比差异性较大，羰基的吸收峰（1736 cm-1）和亚甲基的吸收峰（2917 cm-1 和2849 cm-1）比较强，说明其中所含大量的小分子萜类、脂肪酸（酯）等低极性成分。以上这些结果在分辨率较高的二阶导数谱与二维相关红外光谱中更为明显。结论：红外光谱技术用于蒙药材及其蒙药不同提取物化学成分的整体变化规律是可行的，且红外光谱法样品制样简单，准确，仪器设备普及性强，可作为蒙药材的整体质量控制和不同提取工艺鉴别的依据。

This study was aimed to apply infrared spectroscopy in the comprehensive composition analysis of original medicinal materials of Mongolian medicine Scutellaria scordifolia and its different solvents extracts. Infrared spectroscopy, second derivative infrared spectroscopy and two-dimensional correlation infrared spectroscopy were used to study the chemical composition variation of Mongolian medicine Scutellaria scordifolia and its different solvents (petroleum ether, ethanol and water) extracts. The results showed that original medicinal materials in the Scutellaria scordifolia presented obvious flavonoids and saccharides characteristic infrared absorption peaks, which demonstrated that the original medicinal materials mainly contained flavonoids and polysaccharides. And the infrared spectra of Scutellaria scordifolia ethanol and water extracts were similar with that of original medicinal materials, which also demonstrated the main contain of flavonoids and polysaccharides. The infrared spectrum of petroleum ether extract showed significant difference with that of the other extracts. The absorption peaks of carbonyl (1736 cm-1) and methylene (2917 cm-1 and 2849 cm-1) were stronger, which meant it had a number of low polarity components, including small molecules terpenoids, fatty acids or ester, and etc. Results obtained and mentioned above were more significant in higher-resolution second derivative spectra and two-dimensional correlation infrared spectroscopy. It was concluded that the application of infrared spectroscopy to study the comprehensive chemical composition variation of Mongolian medicinal materials and different solvents extracts is feasible.And the infrared spectrometry with simple sample preparation, high accuracy and strong instrument popularity, can be used as the basis of comprehensive quality control of Mongolian medicinal materials and evaluation of different extraction processes.

国家自然科学基金地区科学基金项目（30860391）：蒙药草乌诃子汤炮制工艺及减毒增（存）效原理的研究，负责人：图雅；中国博士后基金项目（20090450444）：草乌类蒙药的质量综合评价方法研究，负责人：图雅。