为研究中药制剂过程中不同因素对人参皂苷Ro 胶束化的影响，指导中药难溶性成分增溶，本文采用介观动力学方法（MesoDyn），考察Ro的临界胶束浓度（CMC）及聚集形态随温度、难溶性药物柴胡皂苷a（SSa）的浓度及体系盐强度的变化。结果表明，常温条件下Ro的CMC 约为1.29%（V/V）；随着温度升高，CMC升高，胶束形成时间延长，不利于Ro胶束形成；难溶性药物SSa可在水溶液中先聚集成核，促进Ro的聚集，从而使其CMC随SSa浓度的增加而显著降低；体系盐强度对Ro的CMC无显著影响。

To get a deep understanding of influencing factors of preparation on micellization of ginsenoside Ro(Ro), mesoscopic simulation had been employed to study the critical micelle concentration (CMC) and morphology changes of Ro with different temperature, concentrations of insoluble drug and salt strength. The results indicate that the CMC of Ro is about 1.29 vol% at room temperature. High temperature tends to inhibit the micellization of Ro and makes higher CMC and longer time for Ro to aggregate. However, the insoluble drug SSa can facilitate the micellization process because the hydrophobic cores formed by SSa molecules induce the aggregation of Ro. The salt strength has little effect on the CMC of Ro.

国家自然科学基金面上项目（81073058/H2806）：基于计算机模拟的中药皂苷类成分复方配伍增溶机理研究，负责人：史新元; 北京市“中药基础与新药研究重点实验室”，负责人：乔延江。