目的：通过与慢性束缚应激造模法比较，探讨居住入侵法制备经前期综合征（PMS）肝气郁证大鼠模型的可行性。方法：以慢性束缚应激造模法为对照，将国外应用较为成熟的居住入侵法用于制备PMS 肝气郁证大鼠造模，并用旷场实验、悬尾实验等行为学方法系统评价造模效果，比较两种造模方法的优劣。结果：两种方法制备的PMS 肝气郁证模型大鼠旷场实验水平得分、垂直得分及总分均无显著性差异（P>0.05）。结论：采用居住入侵法制备PMS 肝气郁证大鼠模型能有效模拟人类由于情质异常引发的经前抑郁及经后抑郁症状消失状态，且克服了慢性束缚应激法躯体刺激明显的缺点，但其造模成功率低，模型稳定性方面也有待进一步考察。

This study was aimed to investigate the feasibility of establishing premenstrual syndrome (PMS) liver-qi depression rat model with resident-intruder paradigm compared to chronic restraint stress. PMS liver-qi depression rat model was prepared with chronic restraint stress and resident-intruder paradigm, respectively. The effect was systematically evaluated through behavioral methods such as open-field test and tail suspension test. Then, results from both groups were compared. The results showed that both chronic restraint stress and resident-intruder paradigm can effectively simulate the state of premenstrual depression and postmenstrual disappearance. The results of open-field test suggested that there was no significant difference between these two methods (P > 0.05). It was concluded that as a social psychological stress method, resident-intruder paradigm can preferably simulate the process of clinical PMS liver-qi depression caused by emotion abnormality, and overcome the disadvantage of obvious body stress of chronic restraint stress method. But the success ratio was too low, and further inspection was needed to examine its stability.

国家重点基础研究发展计划（“973”计划）资助项目（2011CB505102）：从肝论治抑郁症、经前期综合征探讨肝主疏泄调畅情志的作用机制，负责人：张惠云；国家自然科学基金重点项目（30930110）：肝疏泄失常与调肝方药对不同脑区功能的影响及其机制研究，负责人：乔明琦；国家自然科学基金面上项目（30973688）：诱发愤怒、郁怒大鼠模型脑中枢关键指标筛选及其评价，负责人：张惠云；山东省科技厅科技发展计划项目（2010GSF10290）：抑郁症情绪反应大鼠模型的脑中枢定位及其机制研究，负责人：乔明琦。