目的：对慢性肾脏病（CKD）3 期患者的中医症状及证候分布规律进行调查，为中医规范化诊治本病提供依据。方法：采用前瞻性研究方法，收集了154 例慢性肾脏病3 期患者的人口学、中医症状及证候学资料，探索CKD3 期中医证候的分布规律。结果：CKD3 期患者以肾气阴（血）虚、肾络瘀痹、风湿内扰、湿热内蕴为基本中医证候，几乎所有的患者均存在肾气阴（血）虚证；辨证分型以气阴（血）虚+肾络瘀痹+风湿内扰+湿热内蕴最多（29.8%），其次为气阴（血）虚+肾络瘀痹+风湿内扰（22.7%）、气阴（血）虚+肾络瘀痹+湿热内蕴（16.2%）和气阴（血）虚+风湿内扰+湿热内蕴（11%）。结论：肾气阴（血）虚证、肾络瘀痹证、风湿内扰证、湿热内蕴证在CKD3 期患者整个病程进展中具有重要意义。

This study was aimed to investigate the distribution pattern of traditional Chinese medicine (TCM) syndrome in patients of chronic kidney disease stage 3 (CKD3) to provide a basis for the standardization of integrative medicine in diagnosis and treatment of CKD3. Multicentric epidemiological field survey was adopted to collect the materials of 154 patients in CKD3, including demography, TCM syndrome for exploring the distribution pattern of TCM syndrome. The results showed that there are four basic patterns in CKD3, such as kidney qi-yin deficiency, blood stasis, wind damp and damp heat. The pattern of kidney qi-yin deficiency covers nearly all patients. The first pattern is the combination of qi-yin deficiency, blood stasis, wind damp, and damp heat (29.8%), the other patterns are the combination of qi-yin deficiency, blood stasis, and wind damp (22.7%), the combination of qi-yin deficiency, blood stasis, wind damp (16.2%), the combination of qi-yin deficiency, wind damp, and damp heat (11%). It was concluded that the Chinese medical patterns of kidney qi-yin deficiency, blood stasis, wind damp and damp heat have significant correlation with CKD3 patients.

科学技术部国家“十一五”科技支撑项目（2006BAI04A07）：慢性肾脏病中医临床证治优化方案的示范研究，负责人：王永钧。