本研究以果蝇为模式生物，应用果蝇全基因组表达谱芯片技术研究刺五加对果蝇睡眠-觉醒相关基因表达的影响，并通过生物信息学中数据分析技术探讨刺五加改善睡眠的机制。研究结果表明，刺五加改善果蝇睡眠的作用是以dco、slo、Nos 和DopR2 等基因为主要参与者的多基因参与的过程和多基因共同调节的结果。

In this study, sleep-deprivation drosophila models were made by the alternative light-dark stimulating at night. On this basis, the acting mechanism was explored by using the microarray technology of whole-genome of drosophila and bioinformatics data analysis techniques. The results indicated that Acanthopanax senticosus has effect on the sleep improvement of drosophila models through the co-regulation of many genes, such as dco, slo, Nos and DopR2.

国家自然科学基金项目（81073077）：四逆散有效组分的改善睡眠作用机理与体内代谢过程研究，负责人：李廷利；福建省自然科学基金青年创新项目（2011D016）：刺五加治疗失眠的药效物质基础及作用机制研究，负责人：许光辉。