海洋中药是祖国中药宝库中的重要组成部分，是海洋经济发展的重要增长点之一，如何加快海洋中药的研发和产业化是现阶段海洋中药研究面临的重大问题。本文在中药“性-效-物质”三元理论指导下，基于“经验挖掘-临床验证-作用机制（靶标筛选）-组分筛选-组分配伍”的原则，探讨海洋中药研究的新思路；通过挖掘海洋中药名优验方，筛选海洋中药有效组分；根据药性寒热配伍原则进行配比，开发疗效确切、组分清楚的新型海洋中药复方。昆海姜辛汤是在中药药性理论指导下，应用数据挖掘技术从历代医家经验中挖掘的海洋中药复方，临床研究发现昆海姜辛汤可明显提高慢性支气管炎疗效，改善痰湿蕴肺证候，具有较好的临床安全性。采用“网络药理学”研究思路和方法，应用化学相似性计算、分子对接及受体-配体结合实验，对昆海姜辛汤中有效组分进行筛选，观察不同配比方案改善的药效作用，阐明昆海姜辛汤治疗慢性支气管炎的物质基础，为其分子机制和配伍机制提供科学依据，为海洋中药研发提供新思路。

Marine medicine is an important part of Chinese medicine and a growth point of the development of marine economy. Current researches of marine medicine had ignored accumulated experience in clinical medicine for thousands of years of development of marine medicine and the guidance of traditional Chinese medicine(TCM) theory. In this article, we proposed a research mode of "Mining experience -Clinical validation-Targets screening-Component screening-Component compatibility-Mechanism study" under the guidance of the hypothesis of" Nature-Effect-Material Trialism" to study marine medicine. Kun Hai Jiang Xin (KHJX) Decoction is a marine formula drawn from the experience of ancient physicians by data mining techniques. Clinical study found that KHJX Decoction can significantly improve the overall clinical efficacy of chronic bronchitis with good clinical safety. Under the guidance of TCM herbal theory, object presented here is based on the work of KHJX Decoction "mining experience - clinical validation". The molecular docking method and receptor-ligand binding assay were applied to screen effective components from herbs of KHJX Decoction and the compatibility plan of effective components under the guidance of the principle of cold and heat effects compatibility. This study is of great significance to clarify the material basis and molecular mechanism of KHJX Decoction in the treatment of chronic bronchitis. It provides a new research mode for marine drug research.

科学技术部国家重点基础研究发展计划（“973 计划”）项目（2007CB512601）：基于四性的中药性-效-物质关系研究，负责人：王振国；山东省人力资源和社会保障厅博士后创新项目（201102036）：基于“性-效-物质”三元理论的海洋中药复方有效组分配伍治疗慢性支气管炎的细胞分子机制研究，负责人：付先军；教育部高等学校博士学科点专项科研基金项目（20123731120001）：基于方剂文献文本挖掘和关联网络的海洋中药用药经验模式研究，负责人：付先军；科学技术部国家高技术研究发展计划（“863 计划”）项目（2013AA093001）：海洋传统药源生物资源挖掘整理研究，负责人：王长云。