目的：观察加减逍遥散治疗面部糖皮质激素依赖性皮炎的临床疗效，探讨其改善面部皮肤屏障功能的作用机制。方法：将100 例患者随机分为两组，50 例治疗组内服加减逍遥散；50 例对照组内服氯雷他定、维生素EC 颗粒。30 天为1 个疗程。测定两组患者治疗前后经皮水分丢失量（TEWL）和皮肤红斑量，并同时检测血清IL-4 变化情况。结果：治疗组与对照组临床有效率分别是82.0%、58.0%。治疗组治疗后TEWL、皮肤红斑量均显著降低（P＜0.05）。治疗组血清IL-4 水平降低幅度明显大于对照组（P＜0.05）。结论：加减逍遥散可修复面部激素依赖性皮炎患者受损的皮肤屏障功能、降低皮肤红斑量，治疗机理可能与调节血清IL-4 有关。

This study was aimed to observe the mechanism of "Jia-Jian Xiao -Yao (JJXY) Powder" improving facial skin barrier function of the hormone-dependent dermatitis patients. A total of 100 patients were randomly divided into two groups. In the treatment group, 50 cases were orally administered with JJXY Powder. In the control group, loratadine and vitamin EC particles were orally administered to the 50 cases. Thirty days is one treatment course. Changes of transepidermal water loss (TEWL), skin erythema amount and IL-4 were detected in patients of both groups before and after the treatment. The results showed that the clinical efficiency of treatment group and control group was 82.0% and 58.0% , respectively. In the treatment group, the TEWL and skin erythema amount were obviously decreased after the treatment (P < 0.05). In the treatment group, the decreasing range of serum IL-4 was significant compared to control group (P < 0.05). It was concluded that JJXY Powder is one of the effective methods for the treatment of facial hormone-dependent dermatitis. It is able to repair facial hormone -dependent dermatitis in patients with impaired skin barrier function and reduce the amount of skin erythema. The therapeutic mechanism may be related to the regulation of serum IL-4.

广西壮族自治区教育厅广西高校人才小高地建设创新团队资助计划（桂教人[2015]34 号）：八桂医学创新团队，负责人：戴铭。