慢性肾脏病（CKD）正日益成为全球性的社会问题，延缓CKD 的进展具有重要经济和社会意义。近年研究发现，结肠是产生尿毒症毒素的重要器官之一，肠源性尿毒素与CKD 的预后密切相关，因此国外学者提出了延缓CKD 进展的肠-肾轴理论（The Theory of Gut-kidney Axis），成为研究的热点。中药结肠给药治疗CKD 在临床广泛应用，大量的临床报道提示其可延缓肾衰进展，但临床研究质量偏低，限制了其进一步推广应用。本研究在广东省中医院肾病科学术带头人——黄春林教授应用通腑泄浊法治疗CKD 思路的指导下，结合最新肠肾轴理论，开展了一系列探索性研究，并提出了进一步临床和实验研究的思路，为日后开展高质量的临床研究，获得高级别的临床证据提供数据和方法学基础。

Chronic kidney disease (CKD) is becoming a global social problem. It is important to slow down the progression of CKD for economic and social concerns. In recent years, it has been found that colon is one of the vital organs which produce uremic toxins. And enterogenous uremic toxins are closely related to the prognosis of CKD. Theory of gut-kidney axis for the slowdown of CKD progression was raised by foreign scholars and became the research hot spot. Colon therapy with traditional Chinese medicine (TCM) has been widely used in clinical practice and is believed to slow down the progression of CKD by numerous clinical reports. However, low research quality and ambiguous results limited its further application. Under the guidance of senior TCM Professor Huang Chunlin, who emphasized the method of draining turbidity through bowels in the management of CKD,from the Nephrology Center, Guangdong Provincial Hospital of Chinese Medicine, as well as the modern theory of gut-kidney axis, we had carried out a series of exploratory researches which will provide data and methodology support for further confirmatory studies and improve its effectiveness.

国家中医药管理局2011 年全国名老中医传承工作室建设项目（2012KT1301）：黄春林全国名老中医药专家传承工作室，负责人：刘旭生；国家中医药管理局中医临床研究基地业务建设科研专项，负责人：刘旭生；国家自然科学基金委青年项目（81202819）：基于肠肾轴理论模型探讨大黄结肠给药改善肾间质纤维化的机制研究，负责人：邹川。