[关键词]
[摘要]
目的:通过收集近10 年国内外医学期刊发表的中风病医案,应用现代科研方法,从中挖掘出中风病的遣方用药规律。方法:运用Microsoft Office Excel 2003 建立现代中风病医案数据库,采用频数分析方法探寻高频药物和药类,采用聚类分析方法探寻关系密切的药物组成的药对和聚类方,总结中风病的用药规律。结果:共收集292 例医案,包括249 味药物,用药总频数为3 692 次,药物频数在5 次以上的药物共有118 味,总频率为93.33%。在常用药物中,共涉及17 类药物。对使用频数在20 次以上的50 味药物进行聚类分析,得出5 个聚类组和16 个药对。结论:平肝息风,清热养阴,通腑泄热,燥湿化痰,益气活血通络仍是现代医家治疗中风病的常用治疗方法。
[Key word]
[Abstract]
This study was aimed to collect stroke cases which were published on domestic and foreign medical journals in recent ten years in order to dig out medication principle of stroke with modern scientific methods.Microsoft Office Excel 2003 was used in the establishment of modern stroke medical records database. Frequency analysis was applied to find the commonly used medicinals and medicine category. Cluster analysis was applied to find the closely related herbal pairs and the cluster prescription in order to summarize the medication principles in stroke treatment. A total of 292 prescriptions, which contained 249 kinds of medicinals, were collected in this research. The total frequency of medicine is 3 692 times. The medicinals used more than five times were 118 kinds. The total frequency was 93.3%. In the most commonly used drugs, 17 kinds of medicinals were used. The clustering analysis was given to 50 medicinals which were used more than 20 times. The results showed five cluster groups and 16 herbal pairs. It was concluded that reducing liver to expel wind,clearing heat and nourish yin, purging fu -organs to eliminate heat, drying dampness and resolving phlegm,supplementing qi and promoting blood circulation, are still principles of stroke treatment by modern traditional Chinese medicine doctors.
[中图分类号]
[基金项目]
国家发改委国家中医临床研究基地业务建设科研专项(JDZX2012067):基于病证结合的破血化瘀、填精补髓法治疗出血性中风的临床评价研究,负责人:王健;科学技术部国家公益性行业科研专项(201007002):中医防治中风病技术转化与社区推广研究-脑出血中医全程适时干预方案的规范化研究与评价,负责人:赵德喜。