目的：观察对药酸枣仁-合欢花对抑郁症患者认知功能及血清脑源性神经营养因子（BDNF）水平的影响。方法：收集抑郁症患者60 例，随机分为两组。酸枣仁-合欢花组30 例，服用酸枣仁-合欢花汤剂；盐酸文拉法辛组30 例，口服盐酸文拉法辛缓释片。两组分别于治疗前及治疗6 周后进行汉密顿抑郁量表（HAMD 量表）评分、威斯康星卡片分类（WCST）测试及血清BDNF 检测。结果：治疗前后两组间HAMD 评分、WCST（总应答数、完成分类数、正确应答数、持续错误数、随机错误数）得分、血清BDNF（神经营养因子）水平无显著性差异。与治疗前比较，治疗后两组患者HAMD 评分、总应答数、完成分类数、正确应答数及血清BDNF 水平明显上升，持续错误数、随机错误数明显减少，差异均有统计学意义（P＜0.0缘或P＜0.01）。结论：酸枣仁-合欢花汤剂具有抗抑郁功效，并能够改善抑郁患者的认识功能，其作用机制可能与提高血清BDNF 水平有关。

This study was aimed to observe effects of herbal pair of semen Ziziphi Spinosae (SZS) and Albizia Julibrissin flower (AJF) on cognitive function and serum BDNF among depression patients. A total of 60 depression patients were enrolled and randomly divided into two groups. In the SZS-AJF group, 30 patients were administered with SZS-AJF decoction. In the control group, 30 patients were administered with venlafaxine hydrochloride sustained-release tablets. Hamilton Depression Rating Scale (HAMD), Wisconsin Card Sorting Test (WCST), and the serum-brain derived neurotrophic factor (BDNF) were detected before treatment and after six weeks of treatment. The results showed that there were no significant differences on the HAMD score, WCST (Response Administered (Ra),Categories Completed (Cc), Correct Responses (Cr), Perseverative Errors (Pe), Non-perseverative Errors (Npe)), serum BDNF before and after treatment between two groups. Compared with pretreatment, HAMD score, Ra, Cc, Cr, serum BDNF were increased after treatment in both groups. The Pe and Npe were decreased after treatment. There was statistical significance between pretreatment and posttreatment (P < 0.05, or P < 0.01). It was concluded that the herbal pair of SZS-AJF has anti-depressant effect. It can improve cognitive function of depression patients. The anti-depressant mechanism of herbal pair of SZS-AJF may be related to the increasing of serum BDNF level.

2012 年度广西教育厅高校科研项目（201203YB111）：合欢花抗抑郁作用的临床研究，负责人：施学丽。