目的：观察补肾调肝中药联合克罗米芬助进小卵泡发育的临床疗效。方法：70 例诊断为小卵泡排卵不孕患者，随机分为2 组，对照组35 例，克罗米芬50~100 mg，连用5 d；治疗组35 例，加用制首乌、枸杞、杜仲、柴胡、郁金、枳壳等补肾疏肝中药治疗。观察临床疗效及卵泡MFD 值。结果：治疗组周期妊娠率43.59%，对照组35.13% ，治疗组疗效明显优于对照组，两组疗效经统计学处理有显著性差异（P<0.05）；LUFS 发生率治疗组7.69%，与对照组29.73%比较差异明显，有统计学意义（P<0.01）；MFD 值（18~28 mm）排卵周期中，对照组周期妊娠率为44.44%与治疗组55.17%相比较，差异有统计学意义（P<0.05），对照组早期流产率为18.75%，与治疗组6.25%相比较差异显著，有统计学意义（P<0.01）。结论：补肾疏肝养阴中药配合克罗米芬从整体助进小卵泡发育，临床疗效显著。

This study was aimed to observe the therapeutic effect of Bushen Tiaogan of traditional Chinese medicine(TCM) herbs combined with clomiphene citrate therapy of promoting small follicular development. A total of 70 small follicle ovulation infertility cases were randomly divided into the control group of 35 cases with the treatment of clomiphene citrate of 50 to 100 mg for 5 days, and 35 cases in the treatment group with TCM herbal medicine of Radix Polygoni Multiflori, Lycium c hinense , eucommia, bupleurum root, turmeric, Fructus aurantii to nourish the kidney and regulate the liver. The clinical efficacy and maximum follicular diameter (MFD) were observed. The results showed that the cycle pregnancy rate in the treatment group was 43.59%, and 35.13% in the control group. The curative effect of treatment group was obviously superior to the control group. There was statistical significance in the curative effect (P < 0.05). The incidence of LUFS was 7.69% in the treatment group, and 29.73% in the control group. There was statistical significance (P < 0.01). The MFD value (18-28 mm) in the ovulation cycle, the cycle pregnancy rate was 44.44% in the control group and 55.17% in the treatment group. There was statistical significance difference (P < 0.05). The early abortion rate was 18.75% in the control group and 6.25% in the treatment group. There was statistical significance difference (P < 0.01). It was concluded that Bushen Shugan Yangyin TCM herbs combined with clomiphene citrate can promote small follicular development with obvious clinical curative effect.

南阳理工学院附属医院科研基金项目（NG2012KYJJ16）：小卵泡排卵不孕症的中医治疗，负责人：张慧珍。