磷脂酶A2 是催化水解磷脂甘油二位酰基释放游离脂肪酸和溶血磷脂的限速酶，其下游产物参与了基因表达、能量代谢、质膜重构、信号转导以及炎症、损伤等多种基本生理病理过程，具有广泛的生物活性。本文介绍了磷脂酶A2 超家族成员及其功能，并对近150 篇文献所涉约100 余种中草药或其配方及其化学成分对磷脂酶A2 活性和（或）含量影响进行梳理和综述，以期对中药相关研究提供参考。

Phospholipase A2 (PLA2) is the speed limit enzyme that liberates the sn-2 fatty acyl chains from phospholipids to yield nonesterified fatty acids and lysophospholipids. Its metabolites have a wide range of biological activity in a series of physiological and pathological process such as gene expression, energy metabolism, plasmalemma reconfiguration, signal transduction, inflammation, trauma, and etc. This review introduced members of the PLA2 superfamily and their functions. And the effect on the activity and/or mass of PLA2 family was summarized with a purpose to promote related research, of which more than 100 items included prescriptions, herbs and their active ingredients in 150 articles were collected from the database.

国家自然科学基金委面上项目（30873416）：桂枝汤苯丙烯类系列化合物与分泌型磷脂酶A2 家族对应作用的探索研究，负责人：姜廷良；国家自然科学基金委面上项目（81073108）：发热大鼠脑组织PGE2 灭活主通路的鉴定及桂枝汤活性成分对之的影响，负责人：李沧海。