目的：观察梓醇对pMCAO 大鼠恢复期早期实时步态的影响，评价其对缺血性卒中的改善作用。方法：将大鼠随机分为6 组，即正常对照组，模型组，阳性药天保宁组，梓醇15、30、60 mg·kg-1 组。于术前进行为期7 天的步态仪行走训练，每3 次。训练完成后，采用线栓法建立永久性大脑中动脉栓塞（pM原CAO）大鼠模型，并于术后3~14 天连续给药，术后第14 天进行实时步态行为检测。结果：术后14 天，与正常组比较，pMCAO 模型大鼠平均步行周期显著延长（P<0.01），绝对值平均体转角明显升高（P<0.05），双足支撑时长缩短（P<0.05），三足支撑时长延长（P<0.01），协调性指标显著增加（P<0.01）。与模型组比较，梓醇30 mg·kg-1 及60 mg·kg-1 组模型动物步行周期、降低绝对值平均体转角显著缩短（P<0.05 或P<0.01）；梓醇30 mg·kg-1 组右前相对于其他三足的协调性指数明显降低（P<0.05），脑缺血动物协调性提高。结论：梓醇可部分改善脑缺血模型大鼠的实时步态行为变化，对缺血性卒中的神经功能有一定保护作用。

This study was aimed to observe the influence of Catalpol on real-time gait analysis of early recovery after permanent middle cerebral artery occlusion (pMCAO) in rats to evaluate its effect on the improvement after cerebral ischemia. Rats were randomly divided into 6 groups, which were the normal control group, model group, Tianbaoning group, Catalpol 15, 30, 60 mg·kg-1 group. Rats were trained on the gait instrument for 7 days before pMCAO, 3 times/day. After the training, pMCAO model was made. And continuous infusion was performed from the 3rd to the 14th day after the operation. Then, the real-time gait behavior was detected on the 14th day. The results showed that 14 days after the surgery, compared with the normal control group, the models had a significant extending in the duty cycle (P < 0.01), and obvious increasing of the average body angle of absolute value (P <0.05), the shortening of the two feet supporting time (P < 0.05), and extending of three feet supporting time (P <0.01), and increasing of the coordination index (P < 0.01). Compared with the model group, the Catalpol of 30mg·kg-1 and 60 mg·kg-1 group has obviously decreased duty cycle and average body angle of absolute value (P < 0.05, or P < 0.01). The Catalpol of 30 mg·kg-1 can obviously reduce the coordination index of the right front foot relative to the other three feet (P < 0.05), which improved the coordination of cerebral ischemia animals. It was concluded that Catalpol can improve the real-time gait behavior changes of cerebral ischemia model rats. Therefore, Catalpol have a neural protective effect on cerebral ischemia.

北京市教育委员会北京优博项目（YB20101002601）：抗栓素防治血管性痴呆的作用及机理研究，负责人：孙建宁；北京中医药大学校级自主课题（532/0100604287）：抗栓素对血管性痴呆的作用研究，负责人：张胜威。