目的：研究双夏汤不同洗脱液的镇静催眠作用。方法：通过测定小鼠自主活动和对戊巴比妥钠阈下剂量诱导睡眠的作用，观察双夏汤水煎液、水洗液、20%、70%和95%醇洗液的镇静催眠作用。结果：双夏汤水煎液、20%和95%醇洗液显著降低小鼠的站立次数,分别为78.5%，78.3%和62.5%；双夏汤水洗液和70%醇洗液能显著降低小鼠自主活动次数（P<0.01）、站立次数（P<0.01）和修饰时间（P<0.05）。双夏汤水煎液能明显缩短小鼠睡眠的潜伏期（P<0.05），延长小鼠睡眠时间（P<0.05），增加小鼠的入睡率。双夏汤水洗液能显著缩短小鼠睡眠潜伏期（P<0.05），增加小鼠的入睡率。结论：双夏汤水煎液和水洗液的镇静催眠作用优于醇洗液。

This article was aimed to study the sedative and hypnotic effects of different eluents of Shuangxiatang(SXT). The effects of SXT water decoction, water eluent, 20%, 70% and 95% alcohol eluent on spontaneous activity and the sleeping induced by subthreshold dose of pentobarbital sodium were measured. The results showed that the SXT decoction, 20% and 95% alcohol eluent can significantly decrease the number of rearing in mice with the percentage of 78.5%, 78.3% and 62.5%, respectively. SXT water eluent and 70% alcohol eluent can significantly decrease the spontaneous activity of mice (P < 0.01), the number of rearing (P < 0.01) and grooming time (P < 0.05). SXT water decoction can significantly shorten sleep latency (P < 0.05), prolong sleep time (P <0.05), and increase rates of sleeping in mice. SXT water eluent can significantly shorten sleep latency in mice (P< 0.05), increase rates of sleeping in mice. SXT water decoction and water eluent have the sedative and hypnoticeffects. And the effects are more than alcohol eluents.

国家自然科学基金委面上项目（81173521）：基于受体学说双夏汤治疗失眠的物质基础及作用机制研究，负责人：孙毅坤。