目的：研究左金胃漂浮缓释片多组分的体内释放行为。方法：不同时间点取家兔胃内容物，处理并制备供试品溶液，采用高效液相色谱法建立各个时间点及全溶样品的图谱，计算体内累积释放度，采用相似因子法评价指标成分之间及指标成分与制剂之间的释放行为。结果：在10 h 内，小檗碱与吴茱萸内酯、吴茱萸次碱的相似因子分别为52、61.5，与制剂的相似因子为66.4，吴茱萸内酯与吴茱萸次碱的相似因子为70，与制剂的相似因子分别为46.5、53.7。结论：在10 h 内，小檗碱的释放行为与吴茱萸内酯、吴茱萸次碱及制剂相似；吴茱萸次碱与吴茱萸内酯及制剂的释放行为相似；而吴茱萸内酯与制剂的释放行为不一致。

This article was aimed to study the multicomponent in vivo releasing rules of Zuojin Gastric Floating Sustained-release Tablet. Stomach contents of rabbits were collected at different times and then prepared into solutions for the study. The HPLC was used to establish fingerprints of each time and fingerprints of completely dissolved samples. The in vivo releasing rates were calculated. The evaluation was made on releasing behaviors among index components as well as between index components and preparations. The results showed that within 10 h, the f2 of berberine and limonin, rutaecarpine, preparation were 52, 61.5, 66.4, respectively. The f2 of limonin and rutaecarpine, preparation were 70, 46.5, 53.7, respectively. It was concluded that within 10 h, the releasing behavior of berberine and limonin, rutaecarpine, preparation was similar. The releasing behavior of rutaecarpine and limonin,preparation was similar. However, the releasing behavior of limonin and preparation was different.

贵州省科学技术厅国际合作计划（黔科合外G 字[2012]7044 号）：左金胃漂浮给药系统同步释放及评价研究，负责人：刘文；贵阳市科技局现代药业计划（筑科合同[2011204]号）：左金胃漂浮给药系统同步释放及评价研究，负责人：刘文。