目的：评价现代中药免煎颗粒治疗慢性前列腺炎的疗效及安全性。方法：确诊为慢性前列腺炎，且符合中医湿热瘀阻型、肾虚型患者120 例，用随机数字表法分为西药组与中药组各60 例。Ⅱ、ⅢA型慢性前列腺炎患者服用甲磺酸左氧氟沙星片，每日2 次，每次0.2 g。ⅢB 型患者服用盐酸特拉唑嗪片2mg，每晚1 次，口服。中药组：湿热瘀阻型患者采用通络清解方（自拟方，主要有萆薢、败酱草、车前子等）治疗；肾虚型患者采用加味五子衍宗丸（主要有菟丝子、杞子、熟地、覆盆子、五味子等）；4 周为1 疗程。结果：中药组的总有效率明显优于西药组（P<0.05）；在改善前列腺炎NIH-CPSI 评分、提高患者生活质量，改善患者症状方面，明显优于西药组；另外，中药可以提升ⅢA 型慢性前列腺炎患者前列腺液中的卵磷脂小体（P<0.05）。同时未发现明显毒副反应，结论：中药免煎颗粒治疗慢性前列腺炎具有较好疗效和安全性。

This study was aimed to evaluate the efficacy and safety of free-frying granules of traditional Chinese medicine(TCM) on treatment of chronic prostatitis. A total of 120 chronic prostatitis patients that were diagnosed with the dampness-heat and blood-stasis syndrome and kidney-deficiency syndrome were divided into the TCM group and western medicine group by random digit table. Category Ⅱ and ⅢA chronic prostatitis were treated with oral administration of Levofloxacin Mesylate Tablets (0.2 g, bid) and the category ⅢB chronic prostatitis was treated with oral administration of Terazosin Hydrochloride Tablets (2 mg, qd). In the TCM group, the dampness-heat and bloodstasis syndrome was treated with Tongluo Qingjie formula (which was self-made formula containing Rhizoma Dioscoreae Hypoglaucae, Herba Patriniae, Semen Plantaginis, and etc.) and the kidney-deficiency syndrome was treated with Jiawei Wuzhi Yanzong pills (which containing Semen Cuscutae, Chinese Wolfberry, Radix Rehmanniae Preparata, Fructus Rubi and Schisandra chinensis, and etc.). Four weeks was one course of treatment. The results showed that the total effective rate of TCM group was better than that of western medicine group (P < 0.05). Effect of TCM group was obviously better than that of western medicine group in the improvement of prostatitis NIH-CPSI score, the quality of life and symptoms of the patients. TCM may increase lecithin corpuscle in prostatic fluid of ⅢA chronic prostatitis (P < 0.05). Meanwhile, no obvious toxiferous and side reactions were found. It was concluded that the free-frying granules of TCM have good efficacy and safety in the treatment of chronic prostatitis.

河南省科技厅重点科技攻关项目（082102310030）：中医药治疗慢性前列腺炎优化方案研究，负责人：孙自学；郑州市科技局科技创新团队（121PCXTD522），负责人：孙自学。