目的：优选接骨木的纯化工艺。方法：以莫诺苷为指标，采用不同型号大孔吸附树脂优选接骨木根皮乙醇提取物的最佳纯化工艺。上样量小于1:250（莫诺苷:树脂）的接骨木醇提取物，水洗脱通过AB-8 型大孔吸附柱色谱，弃去20 倍柱体积的水洗脱液，以10%乙醇完全洗脱，洗脱液，浓缩，冷冻干燥，即得接骨木总苷。结果：总苷中莫诺苷含量大于50%。结论：该提取工艺简单、可靠、重复性好，适用于工业生产。

This study was aimed to optimize the purification technology for Sambucus williamsii Hance. With the morroniside as a marker, the purification technology for Sambucus williamsii Hance was optimized by different types of macroporous resin. The results showed that the optimum purification technology was that, the extract of less than 1:250 (morroniside:resin) was adsorbed and the AB-8 resin was washed with distilled water, and then the morroniside was eluted from the macroporous resin with 10% ethanol. And the content of the morroniside was more than 50%. It was concluded that the purification technology was simple, reliable, repeatable and suitable for industrial production.

国家自然科学基金委面上项目（81173501）：接骨木促进骨折有效成分及作用机制研究，负责人：杨炳友；黑龙江中医药大学优秀创新人才支持计划（B201201）：接骨木促进骨折有效成分及作用机制研究，负责人：杨炳友；黑龙江中医药大学博士创新基金项目（B201003）：莫诺苷类化合物的构效关系研究，负责人：韩华。