目的：研究D-核糖对疲劳小鼠骨骼肌组织内高能磷酸物质代谢的影响。方法：通过小鼠负重游泳的方法造疲劳模型，将疲劳小鼠用对位分组法分为模型组、核糖组、咖啡因组以及核糖咖啡因组，灌胃给药，3 次/日，并继续游泳3 天，记录游泳时间，游泳结束后，除即刻取材的小鼠外，其他小鼠继续给药，继续给药3 天后取材。分别取小鼠腓肠肌，高效液相测腓肠肌内的ATP、ADP、AMP、IMP 含量。结果：与模型组相比，核糖组、核咖组小鼠游泳时间明显延长，恢复3 天后核糖组小鼠腓肠肌内ATP、AMP、IMP 的含量显著增加，核咖组小鼠腓肠肌内ATP、AMP、ADP 的含量显著增加，咖啡因组小鼠无明显差异。结论：D-核糖进入机体参与骨骼肌组织内高能磷酸物质代谢，可促进疲劳小鼠腓肠肌中ATP 含量的恢复，延长疲劳小鼠游泳时间，具有一定的抗疲劳作用。

This article was aimed to study effect of D-ribose on the high-energy phosphate metabolism of skeletal muscle tissues of tired mice. The model was made by burden swimming. And then, the mice were divided into four groups, which were the model group, D-ribose group, caffeine group, and D-ribose with caffeine group). Intragastric administrations of drugs were given to all mice in four groups, three times per day. And all mice continued to swim for three days. The time of swimming was recorded. Gastrocnemius of mice were removed after swimming or 3 days later to measure the concentration of ATP, ADP, AMP and IMP with the HPLC. The results showed that compared with the control group, the time of burden swimming was significantly prolonged for mice in the D-ribose group and the D-ribose with caffeine group. After three-day recovery, the concentration of ATP, AMP and IMP of gastrocnemius in the D -ribose group and the D -ribose with caffeine group mice was significantly increased.There was no significant difference in the caffeine group mice. It was concluded that D-ribose is involved in the high-energy phosphate metabolism of skeletal muscle tissues of tired mice. D-ribose promotes the recovery of ATP concentration in the gastrocnemius of tired mice, and prolongs the time of burden swimming. Therefore,it has a certain anti-fatigue effect.

北京中医药大学科研创新团队项目（2011-CXTD-12）：中药复方药物动力学研究创新团队，负责人：石任兵。