目的：观察对药酸枣仁-合欢花对老年抑郁症患者生活质量的影响。方法：收集老年抑郁症病例70 例，随机分为中药组和西药组，各35 例。中药组服用酸枣仁-合欢花汤剂；西药组服用盐酸文拉法辛缓释片。两组分别于治疗前及治疗8 周后进行HAMD 抑郁量表、生活质量综合评定问卷（GQOLI-74）和副作用量表（TESS）评分。结果：治疗后两组间临床疗效无显著差异；生活质量综合评定方面：中药组患者躯体功能维度、心理功能维度及生活质量总分高于西药组，差异有统计学意义（P<0.05）。物质生活维度、社会功能维度与西药组无显著差异；治疗后两组患者的HAMD 评分、躯体功能维度、心理功能维度、社会功能维度、生活质量总分均高于治疗前，差异均有统计学意义（P＜0.05）。中药组TESS 评分低于西药组，其不良反应主要为恶心呕吐。结论：酸枣仁-合欢花汤剂具有抗抑郁功效，能够改善老年抑郁患者的生活质量。

This study was aimed to observe the effects of herbal pair of Semen ziziphi spinosae (SZS) and Albizia julibrissin flower (AJF) on the quality of life (QOL) among elderly patients with depression. A total of 70 elderly patients with depression were enrolled and randomly divided into two groups. The Chinese medicine group (with 35 cases) was given SZS -AJF decoction, and the western medicine group (with 35 cases) was given venlafaxine hydrochloride sustained-release tablets. The HAMD scale score, QOL Assessment Questionnaire (GQOLI-74), and the Side-Effects Scale Score (TESS) were detected 8 weeks before and after the treatment. The results showed that there was no significant difference on the clinical efficacy between two groups. On the comprehensive assessment of QOL, the physical function dimension, mental function dimension and QOL total score of Chinese medicine group were higher than the western medicine group with significant difference (P < 0.05). There were no significant differences on the material function dimension or social function dimensions between two groups. The HAMD score,physical function dimension, mental function dimension, social function dimension and score of QOL were all higher than the pretreatment score with significant differences in both groups (P < 0.05). The TESS score in Chinese medicine group was lower than the western medicine group. And the main adverse reactions in the Chinese medicines group were nausea and vomiting. It was concluded that the herbal pair of SZS and AJF had antidepressant efficacy. It can improve the QOL among elderly patients with depression.

2013 年广西卫厅中医药民族医药继承创新工程立项课题（GZPT13-01）：对药酸枣仁—合欢花抗抑郁作用的临床研究，负责人：施学丽。