目的：研究中西药复方蛇脂清癣软膏对真菌感染动物的治疗作用及抗炎作用。方法：采用红色毛癣菌和羊毛状小孢子菌感染的豚鼠模型，观察硝酸咪康唑与蛇油、苦参等中药合用制成的蛇脂清癣软膏（SZQX 软膏）经皮肤给药后的抗真菌感染作用；并同时观察其对巴豆油所致小鼠耳肿胀、角叉菜胶诱发大鼠足肿胀的影响。结果：SZQX 软膏对红色毛癣菌和羊毛状小孢子菌分别感染的豚鼠有保护作用，可明显降低感染豚鼠局部皮损的镜检评分（P<0.01），效果优于中西药单独运用；SZQX 软膏还能显著减轻巴豆油致小鼠耳肿胀程度、减轻角叉菜胶诱发的大鼠足肿胀程度（P<0.05 或P<0.01），具有明显的抗炎作用，且优于中、西药单独运用。结论：SZQX 软膏具有明显的抗真菌感染及抗炎作用。

This article was aimed to study the therapeutic effects and anti-inflammatory effects of Chinese and western medicine ointment on fungal infection animals. Guinea pig models which were infected with Trichophyton rubrum or Microsporum lanosum were applied to observe the effects of antifungal infections on She -Zhi Qin-Xian (SZQX)ointment by transdermal administration. The ointment is the combination of miconazole nitrate, snake oil and Sophora flavescens which is traditional Chinese medicine (TCM). Simultaneously, the models of croton oil-induced mouse ear swelling and carrageenan-induced rat paw swelling were established to observe the curative effect of SZQX ointment.The results showed that the SZQX ointment had a protective role on both guinea pig models. The microscopic scale of localized lesions in infected guinea pigs was significantly decreased (P < 0.01). The effect of SZQX ointment was better than the single using of Chinese or western medicine. The SZQX ointment was also able to significantly reduce the croton oil-induced mouse ear swelling and carrageenan-induced rat paw swelling (P < 0.05, or P < 0.01) with distinct anti-inflammatory effect. And the effect of SZQX ointment was superior to the single using of either Chinese or western medicine. It was concluded that the SZQX ointment had significant antifungal infection and anti-inflammatory effect.

科学技术部国家重大新药创制项目（2013ZX09402203）：现代中药创新集群与数字制药技术平台，负责人：王振中。