目的:研究江苏省东海县金银花药材基地不同采收期金银花中绿原酸和木犀草苷动态变化规律，确定金银花药材的最佳采收期。方法:采用2010 年版《中国药典》金银花含量测定方法测定绿原酸、木犀草苷含量，结合液相指纹图谱技术和干花收率等指标考察金银花药材三青期、二白期、大白期、银花期及金花期的质量。结果:不同花期金银花中绿原酸、木犀草苷含量存在明显变化，干花质量与产量也存在明显变化。结论:江苏省东海县药材基地金银花最佳采收期为二白期与大白期，与地道产地一致。

This study was aimed to acquire the dynamic changes of chlorogenic acid and luteoloside of honeysuckle at different collecting periods in order to decide the best harvesting time of honeysuckle in Donghai County, Jiangsu Province. The content determination method used in the detection of chlorogenic acid and luteoloside of honeysuckle was from the 2010 edition of the Chinese Pharmacopoeia. The skills of HPLC fingerprint characteristic features, and the yield of pressed flowers were combined in the evaluation of honeysuckle at the three-green period, two-white period, great-white period, silver-flower period and the golden-flower period. The results showed that the content of honeysuckle at different blossoming stages had obvious changes in content of chlorogenic acid and luteoloside, as well as the pressed flower quality and yield of the flower. It was concluded that the optimal harvest time of honeysuckle was for the two-white period and the great-white period, which was consistent with the real origin.

科学技术部国家重大新药创制项目（2013ZX09402203）：现代中药创新集群与数字制药技术平台，负责人：王振中。