目的：优选牡丹皮中丹皮酚的最佳提取工艺。方法：以丹皮酚为指标，采用正交试验法优选最佳提取工艺。结果：最佳提取工艺为加15 倍量水浸泡0.5 h，蒸馏提取2.5 h，收集馏出液，冷却至室温后，4℃下析晶24 h，过滤，室温干燥48 h。结论：优选的提取工艺稳定、合理、可行，丹皮酚提取率达到80%以上。

This article was aimed to study the optimum extraction process of paeonol. The extraction yield of paeonol was taken as investigation index. And the best extraction process was screened by orthogonal experimental design.The results showed that the optimum condition of extraction process was to soak coarse powder of Paeonia suffruticosa into 15-fold water for 0.5 h, and then the distillation lasted for 2.5 h. The distillate was collected and cooled to room temperature. The crystallization lasted for 24 h at 4℃, and then filtered and dried for 48 h at room temperature. It was concluded that the selected technology was stable, reasonable and feasible. The extraction yield of paeonol is over 80%.

科学技术部国家重大新药创制项目（2013ZX09402203）：现代中药创新集群与数字制药技术平台：王振中。