[关键词]
[摘要]
目的:对青蒿素哌喹片进行鉴别。方法:采用不同溶剂提取青蒿素哌喹片中的青蒿素和哌喹,分别测定各自红外谱图。结果:除了青蒿素红外光谱图在1 574 cm-1 处出现一组哌喹干扰峰外,青蒿素哌喹片经提取后的红外谱图均与《药品红外光谱集》中青蒿素和哌喹标准谱图一致。结论:该方法稳定可靠、专属性强,可用于青蒿素哌喹片的鉴别。
[Key word]
[Abstract]
Infrared (IR) spectroscopy was employed to identify the Artemisinin and Piperaquine Tablets. Artemisinin and piperaquine was extracted separately by different solvents, and IR spectra were collected. IR absorption spectrum of the extract was concordant with the reference spectrum recorded in the Atlas of Infrared Spectra of Drugs, except for a group of small absorptions at 1 574 cm-1 for the artemisinin extract. It was concluded that IR method is stable and accurate, which can be used to identify the Artemisinin and Piperaquine Tablets.
[中图分类号]
[基金项目]
经全球基金理事会批准和受中国医药国际交流中心委托,国家药典委员会组织开展的中国全球基金TB 结核病项目卫生系统加强(HSS)药 品质量标准提高项目(2010-2013 年)青蒿素哌喹片国家标准起草(GF2012-40),负责人:王铁杰。