目的：使用中药代谢安颗粒对老龄代谢综合征（MS）大鼠进行干预治疗，研究其对老龄大鼠MS 相关指标及对老年MS大鼠神经元和微血管损伤的病理生理作用。方法：对老龄大鼠给予高脂饲料建立MS动物模型，并对模型进行评价，在中医理论指导下，探索代谢安对老年MS 大鼠一般情况、糖脂代谢、胰岛素敏感性等一系列指标的影响，观察其对大鼠脑神经元和微血管损伤的作用。结果：代谢安能改善老年MS 大鼠糖脂代谢紊乱状态，降低血清总胆固醇（TC）、甘油三酯（TG）、TC/高密度脂蛋白（HDL）比值，降低血糖、血清胰岛素水平，改善胰岛素抵抗状态，减少腹腔脂肪蓄积；代谢安能减少大鼠脑神经元细胞的凋亡，增加微血管新生。其作用均和罗格列酮相近。结论：对于老年MS大鼠，代谢安能够改善其糖脂代谢紊乱并保护脑神经元及微血管损伤。

This article was aimed to study the therapeutic effect of Chinese medicine Dai-Xie-An (DXA) granules among aging rats of metabolic syndrome (MS) in order to evaluate relative indicators and the pathophysiological role in neurons and microvascular injury among aging MS rats. Aging MS rat model was established by feeding high-fat diet and the established model was evaluated. Under the guidance of traditional Chinese medicine (TCM) theory, metabolic indexes, such as general state of health, glycolipid metabolism, insulin sensitivity, were explored in order to observe effects on brain neurons and microvascular injury among aging MS rats. The results showed that DXA granules can improve glycolipid metabolism among aging MS rats, decrease TC, TG, TC/HDL, decrease the level of blood sugar and serum insulin, improve insulin resistance, decrease abdominal fat accumulation, reduce neuronal apoptosis, and increase microvascular angiogenesis. These effects are similar to rosiglitazone. It was concluded that DXA granules can ameliorate glycolipid disorders, protect brain neurons and microvascular injury of aging MS rats.

河南省科技厅基础与前沿技术研究项目（092300410057）：代谢综合征血管内皮损伤的炎性机制，负责人：于海滨。