目的：建立电感耦合等离子体质谱法（ICP-MS）测定片仔癀肝宝中铬（Cr）、铅（Pb）、镉（Cd）、砷（As）、汞（Hg）、铜（Cu）6种重金属的含量。方法：样品微波消解处理后，采用电感耦合等离子体质谱法测定。结果：Cr、Cu、As、Cd、Hg、Pb标液的工作曲线线性良好，相关系数大于0.999 3。其中Cr的平均回收率101.2%，相对标准偏差（RSD）7.6%；Cu的平均回收率96.4%，RSD3.5%；As的平均回收率101.3%，RSD1.8%；Cd的平均回收率100.2%，RSD0.3%；Hg的平均回收率100.5%，RSD4.2%；Pb的平均回收率104.2%，RSD5.6%。结论：该方法稳定可靠，灵敏度高，重现性好，可用于测定片仔癀肝宝中Cr、Cu、As、Cd、Hg、Pb 6种重金属的含量。

This study was aimed to develop an ICP-MS method to determine contents of six types of heavy metals, which include Cr, Pb, Cd, As, Hg and Cu, in Pian-Zai-Huang Gan-Bao (PZHGB) tablets. The samples were processed by microwave digestion. And then, they were determined by ICP-MS. The results showed that the working curves of Cr, Cu, As, Cd, Hg and Pb had good linear relationships with the correlation coefficient which was more than 0.9993. The average recovery rate of Cr was 101.2%. The relative standard deviation (RSD) was 7.6%. The average recovery rate of Cu was 96.4%, with the RSD of 3.5%. The average recovery rate of As was 101.3%, with the RSD of 1.8%. The average recovery rate of Cd was 100.2%, with the RSD of 0.3%. The average recovery rate of Hg was 100.5%, with the RSD of 4.2%. The average recovery rate of Pb was 104.2%, with the RSD of 5.6%. It was concluded that the method was stable and reliable, with high sensitivity and repeatability. This method can be used in the content determination of six types of heavy metals, which include Cr, Pb, Cd, As, Hg and Cu in PZHGB tablets.

漳州片仔癀药业股份有限公司自主课题（2008ZX09202-010）：片仔癀药效作用机理及质控体系的研究，负责人：潘杰。