观察电针治疗2型糖尿（T2DM）病肥胖患者的疗效。方法：电针治疗203例T2DM伴肥胖患者。观察治疗3 个月前后患者空腹血糖（FBS）、空腹胰岛素（FINS）、胰岛素敏感指数（ISI）、胰岛素抵抗指数（Homa-IR）、胰岛素分泌指数（Homa-茁）、肥胖度（A）、体质量（Kg）、体质指数（BMI）和体脂百分率（F%）的变化，观察肥胖和证型对电针降糖疗效的影响。结果：与治疗前相比，203例患者经治疗后，FINS、Homa-IR、FBS都有显著回降（P<0.01），ISI、Homa-β显著回升（P<0.01），治疗前后比较胰岛β细胞功能改善均有显著统计学意义；A、体质量、BMI、F%均显著下降（P<0.01）。肥胖能影响电针加耳针降糖疗效，证型无影响。结论：电针能显著纠正T2DM伴肥胖患者的血糖，保护胰岛茁细胞功能，并且能降低患者体质量。

This study was aimed to observe the effect of electro-acupuncture (EA) treatment on Zhong-Xiao (ZX,T2MD) with obesity. A total of 203 patients with ZX accompanied with obesity accepted EA treatment. Before and after 3-month treatment, observations were made on patients' fasting blood glucose (FBS), fasting insulin (FINS), insulin sensitivity index (ISI), insulin resistance index (Homa-IR), insulin secretion index (Homa-β), degree of obesity (A), body mass (Kg), body mass index (BMI) and body fat percentage (F%) changes. The results showed that compared with pretreatment, the posttreatment FINS, Homa-IR, FBS had a significant decrease among 203 patients (P <0.01); the ISI and Homa-β had a significant increase (P < 0.01). There was a significant statistical difference on islet β-cell function before and after treatment. The A, body mass, BMI, and F% were significantly decreased (P <0.01). It was concluded that EA can significantly correct ZX with obesity patients' glucose consumption, protect the islet β-cell function, and reduce the body mass of patients.

国家自然科学基金委面上项目（39770929）：针刺减肥作用的细胞分子机制，负责人：刘志诚；教育部高等学校博士学科点专项科研基金（20040315008）：针灸治疗2 型糖尿病胰岛素和瘦素抵抗的细胞分子机制，负责人：刘志诚。