槟榔十三味丸源于19世纪著作《蒙医金匮》，在该书中名为高尤-13，首载槟榔十三味丸方名者为1977年版《吉林省药品标准》。本方曾用名为泰德乎然古鲁格其乃然塔、色么吉德吉德等，《通瓦嘠吉德》虽载色么吉德吉德，但为同名异方，与今之用槟榔十三味丸无渊源关系。槟榔十三味丸在不同时期药物组成有13、14、15味不同，至少出现5个不同药物组成的高尤-13，方药演变集中在19—20世纪上半叶，自1971年以后方药组成和配比均无发生大的变化。其中，槟榔、广枣、木香、丁香、肉豆蔻、紫硇砂、干姜、荜拔、胡椒、沉香等10味药物是固定不变的，单味药物配比变化较大的属制草乌，其次有木香、丁香、沉香。《吉林省药品标准》、《中华人民共和国卫生部药品标准?蒙药分册》所载槟榔十三味丸虽未标注其来源，但根据方药组成及配比认为来源于《蒙医金匮》，《内蒙古蒙成药标准》注其来源于《蒙医金匮》。3部标准与《蒙医金匮》载高尤-13药物组成除野牦牛心外均一致，唯独制草乌配比有所不同，其余药物配比均相同。只有《内蒙古蒙成药标准》在附录中标注了与原方的区别，其余两部标准也应与原方异同进行标注为妥。

Betel Shi-San-Wei Ingredients Pill(BSSWIP) was first recorded in the 19th century writings "Meng-Yi Jin-Gui" with the name of Gao-You-13. The name of BSSWIP was first recorded in the book of the 1977 edition of the "Drug Standard of the Jilin Province", which was formerly known as Tai De Hu Ran Gu Lu Ge Qi Nai Ran Ta, Se Me Ji De Ji De, and etc. Although in the book of "Tong-Wa-Ga-Ji-De", Se Me Ji De Ji De was documented, it was the same name of different compositions. It had no original relation with BSSWIP. In different periods, the BSSWIP was consisted of 13, 14 or 15 kinds of herbs. There were at least five different types of herbs appeared in the Gao-You-13. The evolution of prescription was mainly from the 19th century to the first half of the 20th century. There was no major change on prescription composition and proportion since 1971. Among them, 10 kinds of herbs, which were Bing-Lang, Guang-Zao, Mu-Xiang, Ding-Xiang, Rou-Dou-Kou, Zi-Nao-Sha, Gan-Jiang, Bi-Ba, Hu-Jiao, and Chen-Xiang were fixed. The ratio of single herbal medicine changed the most was Zhi-Cao-Wu, which was followed by Mu-Xiang, Ding-Xiang and Chen-Xiang. There were no marked sources of BSSWIP in the recording of the "Drug Standard of the Jilin Province" and the "Mongolian Medicine Volume ? Ministry of Health of the People's Republic of China". The composition and proportion were considered to be from the book "Meng-Yi Jin-Gui" according to notes of "Standards on Mongolian Patent Medicine in Inner Mongolia". Recordings of three standards are in consistence with the "Meng-Yi Jin-Gui" on Gao-You-13 except for Ye-Mao-Niu Xin and the different ratio of Zhi-Cao-Wu. In the appendix of the "Standards on Mongolian Patent Medicine in Inner Mongolia", it marked the differences from the original prescription. Therefore, the other two criteria should also mark the similarities and differences compared with the original prescription properly.

国家自然科学基金委青年科学基金项目（81202998）：基于cAMP-CREB-BDNF信号通路的蒙医“镇赫依法”促进抑郁症海马神经元再生的作用及机理研究，负责人：佟海英；北京市自然科学基金委面上项目（7122202）：槟榔十三味丸调节HPA轴激素分泌及负反馈功能的抗抑郁机理研究，负责人：佟海英。