目的：研究桑白皮水煎液及各化学拆分组分对糖尿病小鼠模型的降糖作用。方法：雄性昆明种小鼠，腹腔注射大剂量链脲佐菌素（STZ）（170 mg ?kg-1），建立Ⅰ型糖尿病小鼠模型，连续给药4周，检测体质量、饮水量、饮食量、空腹血糖（FBG）、胰岛素、C肽、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇（LDL-c）等指标，光镜观察肝脏、胰腺病理形态。结果：桑白皮水煎液高剂量组能增加Ⅰ型糖尿病小鼠体质量，明显降低饮水量、饮食量，并能不同程度地降低FBG、TC、TG、LDL-c水平（P<0.05或P<0.01），升高C肽、HDL-c水平（P<0.05或P<0.01）。桑白皮30%乙醇组分及脂肪油组分给药量约为桑白皮水煎液的1/2和1/4时，均能显著改善糖尿病小鼠糖脂紊乱状况，修复肝脏细胞，改善肝脏组织损伤，且作用优于桑白皮水煎液。结论：桑白皮水煎液具有较好的降糖作用，其有效部位为30%乙醇组分和脂肪油组分，降糖作用机制可能与促进胰岛素分泌、调节血脂紊乱，保护肝脏结构和功能有关。

This article was aimed to study effects of aqueous extracts and all chemical split fractions of Mori Cortex on hypoglycemic effect of diabetic mice model. Intra-peritoneal injection of 170 mg?kg-1 streptozocin (STZ) was given to male Kunming mice to establish type I diabetes mode. Continuous administration of medication was given for 4 weeks. And then, indicators such as body weight, water intake, food intake, fasting plasma glucose (FBG), insulin, C-peptide, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-c), and low density lipoprotein cholesterol (LDL-c) were detected. Pathological morphology of the liver and pancreas were observed by light microscopy. The results showed that high-dose group of M. Cortex aqueous extracts can improve weight loss of type I diabetic mice, significantly reduce water intake and food intake, reduce FBG, TC, TG and LDL-c levels in different degrees (P<0.05 or P<0.01), and increase C-peptide and HDL-c levels (P<0.05 or P<0.01). When dosages of 30% ethanol fraction and fatty oil fraction were only about 1/2 and 1/4 of M.Cortex aqueous extracts, we found that it can improve lipid disorder status, repair liver cells, and improve liver tissue damage. Its effect was superior to M. Cortex aqueous extracts. It was concluded that M. Cortex aqueous extracts showed a better hypoglycemic effect. The effective component parts were 30% ethanol fraction and fatty oil fraction. Its hypoglycemic mechanism may be related to the promotion of insulin secretion, regulation of blood lipid disorders, as well as the protection of liver structure and function.

科学技术部国家重点基础研究发展计划“973计划”项目（2013CB531802）：宣泻利水中药的药性研究，负责人：郑晓珂。