金属（半金属）元素在机体内具有较多的生理生化作用，多项研究表明，金属元素与中医证候及中药药效的发生、发展有一定的相关性。本文将从金属元素在中医证候、中药药性理论、中药药效、中医组方原理、中药炮制理论以及中药质量控制等方面的研究现状作以介绍；指出目前从金属元素入手进行中医药研究的不足，介绍系统生物学“组学家族”成员—金属组学的概念及其在中医药领域中的应用前景。

Metal or semi-metal elements have numerous physiological and biochemical properties and have correlations with the process of occurrence and development of Zheng and Chinese herbal medicine pharmacodynamics mechanism. This article will expound the current situation of traditional Chinese medicine (TCM) research based on metal elements from the researches of Zheng, medicine theory, pharmacodynamic mechanism, prescription principles, medicine concocted theory and medicine quality control in TCM. In addition to putting forward the shortages of current researches, we also introduce metallomics, the member of Omics in systems biology to offer a new idea for modernization of TCM based on metal elements.

国家自然科学基金委面上项目（81373519）:基于整体代谢网络的异病同证（三焦）湿热证的证候基础及病变机制研究，负责人：张永煜；国家“十二五”重大专项（2012ZX10005001-002）：基于转化医学的慢性乙型病毒性肝炎中医证候生物学研究，负责人：胡义扬；上海市学位委员会[（2012）13号]：研究生交叉学科创新人才培养平台建设项目，负责人：张永煜；上海市高校一流学科建设（A类），负责人：王峥涛。