目的：依托观察慢性前列腺炎患者治疗前后炎症介质及血流变的变化，比较祛瘀通闭汤规范保留灌肠对慢性前列腺炎和使用α-受体阻滞剂和喹诺酮类抗生素联合治疗的疗效差异性。方法：将同期在河南省中医院就诊的164例患者随机分为观察组和对照组，每组62例，观察组使用祛瘀通闭汤规范保留灌肠治疗慢性前列腺炎，对照组使用α-受体阻滞剂和喹诺酮类抗生素联合治疗。疗程1月，对比两者差异性。结果：观察组总有效率为79.03%（49例），与对照组总有效率61.29%（39例）相比，差异有统计学意义（P<0.05）；两组患者治疗前后TNF-α、IFN-γ及NIH-CPSI评分对比，差异有统计学意义（P<0.05），与对照组比较，观察组治疗后TNF-α、IFN-γ及NIH-CPSI评分差异显著（P<0.01）；对照组治疗前后全血粘度（高切）、血浆粘度和红细胞压积测试值对比均无明显差异。观察组治疗前后全血粘度（高切）和血浆粘度测试值对比，差异有统计学意义（P<0.05），但红细胞压积测试值对比无明显差异。结论：两种治疗方法对于慢性前列腺炎均具有一定疗效，但是祛瘀通闭汤规范保留灌肠治疗慢性前列腺炎的疗效明显优于喹诺酮类抗生素合并α-受体阻滞剂方式。

Through observation on changes of inflammatory mediators and hemorrheology among chronic prostatitis patients before and after treatment, this study was aimed to compare the therapeutic differences between the applications of standard retention enema of Qu-Yu Tong-Bi (QYTB) decoction and α-blockers combined with quinolones. During the same period, 164 patients of the Henan Province of Traditional Chinese Medicine Hospital were randomly divided into the observation group and control group, with 62 cases in each group. Retention enema of QYTB decoction was given in the observation group; and α-blockers combined with quinolones were used in the control group. The treatment course was one month. And the differences were compared. The results showed that the total effective rate of the observation group was 79.03% (49 cases); and that of the control group was 61.29% (39 cases). There was statistical significance between two groups (P < 0.05). There was statistical significance on TNF-α, IFN-γ and NIH-CPSI score comparison before and after treatment of two groups (P < 0.05). Compared to the control group, the posttreatment TNF-α, IFN-γ and NIH-CPSI score in the observation group had significant difference (P < 0.01). There were no significant differences on the whole blood viscosity (high shear), plasma viscosity and erythrocyte deposited test value contrast between pretreatment and posttreatment in the control group. There were significant differences on the whole blood viscosity (high shear) and plasma viscosity between pretreatment and posttreatment in the observation group (P < 0.05). However, there was no significant differences on erythrocyte deposited test value contrast. It was concluded that both methods had certain therapeutic effect in the treatment of chronic prostatitis. However, the effect of retention enema of QYTB decoction was better than the treatment of quinolones combined with α-blockers.

河南省中医管理局中医药科学研究专项（2014ZY02069）：基于血流变与炎症介质行祛瘀通闭汤保留灌肠治疗慢性前列腺炎血瘀型疗效判定，负责人：琚保军；河南省教育厅自然科学研究计划项目（2008A360025）：慢性前列腺炎常见中医证型与细胞因子相关性研究，负责人：王祖龙。