阐述补肾健脾化痰法论治肥胖型多囊卵巢综合征（PCOS）伴发胰岛素抵抗（IR）的信号转导分子机制研究进展，探讨该治法对肥胖型PCOS伴IR的作用机制，为中医妇科临床运用该治法治疗肥胖型PCOS提供研究思路。运用中医传统理论及现代信号通路文献分析脾肾亏虚、痰湿内蕴是本病伴IR的关键病机，并论证从补肾健脾化痰法论治肥胖型PCOS伴发IR方法的科学性，创新性提出运用补肾健脾化痰法论治该病信号转导分子机制的研究策略是以PI-3K/Akt信号通路与TNF-α信号通路的交互对话为靶点，探讨该治法对本病伴发IR的调控作用及产生机制。

This paper elaborated the research progress on transduction mechanisms of obese polycystic ovary syndrome (PCOS) and insulin resistance (IR). The action mechanisms of kidney-tonifying, spleen-invigorating and phlegm-resolving in the treatment of obese PCOS and IR were explored. It provided new ideas for the treatment of obese PCOS patients in the clinical practice of traditional Chinese medicine (TCM) gynecology. Literatures on TCM theories and modern signal pathways were used in the analysis of spleen-kidney deficiency and phlegm-dampness retention, which were the key pathogenesis of obese PCOS and IR. The scientific nature of treating obese PCOS and IR from the method of kidney-tonifying, spleen-invigorating and phlegm-resolving was demonstrated. The results showed that the scientific nature of treating obese PCOS and IR from the method of kidney-tonifying, spleen-invigorating and phlegm-resolving was initially demonstrated by the organic combination of TCM and modern medicine theories. It innovatively proposed that the treatment study strategy of transduction molecular mechanism took the interactive dialogue between PI-3K/Akt signal pathway and TNF-α signal pathway as its target. The regulatory role and action mechanism of this method in the treatment of obese PCOS and IR were discussed.

国家自然科学基金委面上项目（81470199）：经APN信号通路探讨补肾化痰法调控肥胖型PCOS卵泡发育机制研究，负责人：徐晓娟；四川省教育厅基础项目（142A0315）：以APN信号途径为靶点研究补肾化痰法调控肥胖型PCOS雌鼠GC增殖分化机制，负责人：徐晓娟。