目的：研究治疗痴呆方剂的用药配伍规律；探讨加减薯蓣丸的用药配伍规律。方法：收集《中医方剂大辞典》中治疗痴呆的方剂，将其规范化后利用Microsoft Office Excel 2007构建数据库，采用SPSS 19.0、Clementine 12.0软件，通过频数分析、关联规则算法数据挖掘方法，研究治疗“痴呆”的方剂用药配伍规律，并对加减薯蓣丸的用药配伍规律进行探讨。结果：治疗痴呆的主要用药为人参、远志、甘草、朱砂、茯神、茯苓、石菖蒲、麦门冬、当归、酸枣仁；主要用药组合为“酸枣仁-当归-远志”、“石菖蒲-朱砂-远志”、“当归-白芍”、“当归-黄芪”、“当归-酸枣仁-远志”、“当归-白芍-人参”、“当归-酸枣仁-人参”、“当归-干地黄”、“远志-石菖蒲-茯苓”、“远志-石菖蒲-人参”、“当归-酸枣仁”、“茯神-朱砂-远志”、“茯神-酸枣仁-远志”、“麦门冬-熟地黄-人参”、“远志-石菖蒲-茯神”和“石菖蒲-茯神-远志-人参”。加减薯蓣丸由补气药、补血药、补阴药、补阳药（共10味）和安神药、利水渗湿药、开窍药、收涩药（各1味）构成。结论：治疗痴呆的方剂主要由补气药、补血药、补阴药、安神药、利水渗湿药、开窍药配伍而成；加减薯蓣丸的配伍遵循治疗痴呆方剂的配伍规律，可用于防治痴呆。

This research was aimed to study the compatibility law of dementia treatment prescriptions and the modified Shuyu Pill.In order to explore the compatibility law,dementia treatment prescriptions were collected from the Dictionary of Prescriptions Traditional Chinese Medicine.The database was established with the Microsoft Office Excel 2007.Software such as SPSS 19.0 and Clementine 12.0 was used.Data mining methods such as frequency analysis and association rule were used in the compatibility law study of dementia treatment prescriptions.And the compatibility law of modified Shuyu Pill was discussed.The results showed that the main herbs in dementia treatment were Renshen(RS),Yuanzhi(YZ),Gancao(GC),Zhusha(ZS),Fushen(FS),Fuling (FL),Shichangpu (SCP), Maimendong (MMD), Danggui (DG), and Suanzaoren (SZR). And its primary combinations were“SZR-DG-YZ”,“SZR-ZS-YZ”,“DG-Baishao”,“DG-Huangqi”,“DG-SZR-YZ”,“DG- Baishao-RS”,“DG-SZR-RS”,“DG-Gandihuang”,“YZ-SCP-FL”,“YZ-SCP-RS”,“DG-SZR”,“FS-ZSYZ”,“FS-SZR-YZ”,“MMD-Shudihuang-RS”,“YZ-SCP-FS”,and“SCP-FS-YZ-RS”.The modified Shuyu Pill mainly consisted with qi,blood,yin and yang tonics(10herbs)and mind-tranquilizing,damp-clearing and resuscitation herb(1herb for each function).It was concluded that the combination in dementia treatment prescription was qi,blood,yin tonics,mind-tranquilizing,damp-clearing and resuscitation herb.The modified Shuyu Pill followed the compatibility law of dementia treatment prescription,which can be used in the prevention of dementia.

湖北省中医院院内重点项目（JDZX2014Z02）：基于代谢组学探讨血管性痴呆不同中医证候相关性及加减薯蓣丸干预机制，负责人：谭子虎。