[关键词]
[摘要]
microRNA(miRNA)是一类长度约为18-25个核苷酸的非编码RNA,参与基因的转录后调控过程。近年研究发现,miRNA在胰腺发育、胰岛素基因的表达、胰岛素的合成和分泌过程中发挥着重要调节作用。胰岛内一些miRNA可影响胰岛β细胞的增殖和分化。miRNA具有组织特异性,其表达改变与某些疾病的发生密切相关;而与中医证候本质的相关联研究可为糖尿病的中医药治疗提供新的思路。
[Key word]
[Abstract]
MicroRNAs(miRNAs)are a class of non-coding RNAs about 18-25 nucleotides in length,involved in post-transcriptional genes regulation process.Previous studies showed that miRNAs played an important regulatory role in pancreatic development,gene expression,and synthesis and secretion of insulin.A variety of miRNAs which expressed in islet β cells may affect the proliferation and differentiation of islet β cells.Since miRNAs showed tissue specificity,their expression changes were closely related to some diseases.Thus,integrative studies with miRNAs over the essence of syndromes of traditional Chinese medicine could provide new ideas for the treatment of diabetes.
[中图分类号]
[基金项目]
国家自然科学基金委青年科学基金项目(81502107):NLRP3 炎性体信号通路诱导胃癌上皮-间质转化及侵袭转移的研究,负责人:王巍;辽宁省教育评价协会第一届教学改革与教育质量评价研究立项课题(PJHYYB15125):病理生理学教学系统整合PBL教学初探,负责人:王巍;教育部2015年国家级大学生创新训练项目省级乙类(2015053):抑癌基因ARHI对胃癌细胞的抑制作用及其机制研究,负责人:王巍;教育部2014年国家级大学生创新训练校级项目(2014090):抑癌基因ARHI对胃癌细胞的抑制作用及其机制研究,负责人:王巍。