穴位敏化是穴位接受刺激因素后激发机体调节功能的动态过程。目前，运用影像学技术的穴位敏化研究尽管已有一定的成果，但仍存在以下局限性：忽略了穴位敏化的时空动态性、忽略了敏化过程中特征性物质的动态变化、特定分子探针尚未得到较好运用。随着分子影像学技术的发展，不仅可以观察到穴位敏化动态过程中的生物物理学变化，还可深入到细胞、分子水平的研究。同时，前沿纳米技术和材料正愈发广泛地应用于生物医学领域。将生物成像技术和纳米生物技术的优势有机结合而产生的纳米生物成像技术，可为穴位敏化的胞内结构研究奠定基础，进而为探讨穴位敏化的物质基础提供科学依据。

Acupoint sensitization is a dynamic process of receiving stimuli and regulating functional activities of the body.Though some desirable results were achieved by applying molecular imaging methods to acupoint sensitization research,there were still some neglected limitations,such as spatiotemporal dynamics,dynamics of some characteristic compound and specific molecular probes.In the surge of the development of molecular imaging techniques,not only biophysical mordifications,but cellular and molecular alterations can be profoundly explored.Frontiers of nanotechnology is used widely in the field of biomedical science.Based on their vantages,nano-bio-imaging technology is the fusion of biological imaging technology and nanobiotechnology.At the cutting edge,the technology provides a foundation for understanding the process of acupoint sensitization in the sight of intracellular structure,outlining the scientific evidence behind the mater ial basis of acupoint sensitization.

国家自然科学基金委面上项目（81473774）：基于“通督启神”法探讨不同电针对AD模型小鼠不同脑区小胶质细胞活化通路的影响，负责人：李志刚；国家自然科学基金委重大项目（81590952）：穴位敏化的客观显像研究，负责人：李志刚。