抑郁症患者心血管疾病高发已成为主要趋势。血小板活化增加是其中重要的作用机制之一。研究显示抑郁与5-羟色胺的增加、血小板的激活有关，P-selectin（CDbzP）是反映血小板活化与释放反应最特异的标志物，而TXB2和6-keto-PGF1α是调控血小板功能最强的一对内源性物质。针刺疗法对改善抑郁症有较好的临床疗效；与西医抗抑郁药相比，针刺具有起效快、毒副作用小、费用低廉等优势。本文基于6-keto-PGF1α/TXB2、P-selectin与抑郁症可能存在的相关性，进一步解释5-HT 和血小板之间的确切关联，结合针灸疗法寻找治疗抑郁症的潜在靶点；并就6-keto-PGF1α/TXB2、P-selectin与抑郁症的关联研究进展作一综述。

Higher morbidity of central vascular disease in patients with depression than in general people is a current trend.Hyperactive platelet is the main cause.Rested on the previous studies, depression linked with the overexpression of serotonin and the activation of platelet.P-selectin(CDbzP)was the most specific marker reflecting the activation and release of platelet,while TXB2 and 6-keto-PGF1α was the strongest pair of endogenous substances that regulate of platelet's function.Acupuncture was effective in allaying depression in clinic,featuring the vantages of fast action,slight side effects and low cost in comparison with antidepressants in western medicine.On account of the possible correlations between 6-keto-PGF1α/TXB 2,P-selectin and depression,exact relevance of depression to 5-hydroxytryptamine and platelet was elucidated.And the potential targets in the treatment of depression by means of acupuncture were explored.In this study,the progress of 6-keto-PGF1α/TXB2 and P-selectin associated with depression were reviewed.

国家自然科学基金委地区科学基金项目（81360576）：基于神经血管单元探讨蒙医“三根平衡针法”干预抑郁模型大鼠的分子生物学机制研究，负责人：赛音朝克图；国家自然基金委面上项目（81072860）：不同电针对慢性应激抑郁模型大鼠不同脑区代谢组学影响，负责人：李志刚；内蒙古自治区科技厅自然科学基金项目（2015MS08130）：基于NO/cGMP通路探讨“三根平衡针法”对抑郁症模型大鼠不同脑区抗氧化效应的研究，负责人：赛音朝克图。