肝硬化属于中医学“癥积”的范畴，其病机之要在于阴精亏虚所致形质虚损，其病理学基础主要表现为肝实质细胞数量的减少、功能的衰退以及肝窦壁的损伤。滋补肝肾是促进精气恢复的根本治疗策略，一贯煎具有长期的临床应用历史及良好的实验研究基础，包括提高肝脏的生物转化功能、提高肝组织的抗氧化应激功能、改善肝脏缺氧状态、保护肝窦内皮细胞、抑制血管新生、调控肝脏干细胞分化取向等。本文就肝硬化肝肾阴虚病机理论形成及一贯煎方证病理学基础进行概述。

Liver cirrhosis was equal to“Zheng Ji”disease in traditional Chinese medicine with the pathogenesis of quality deficiency caused by yin deficiency and its pathological basis involving the cell count’s reduction and the weakened function of hepatic parenchymal cells and the injury of liver sinusoidal wall.Nourishing the liver and kidney was the critical treatment strategy,of which Yi Guan Jian presented a favorable experimental research foundation with a long history of clinical application,including the improvement of liver biotransformation function,the antioxidant function and liver hypoxia,the protection of hepatic sinusoidal endothelial cells,inhibition of angiogenesis and the regulation of liver stem cell differentiation, etc.In this paper,the mechanism of liver- and kidney-yin deficiency,the pathogenesis theory of cirrhosis were summarized with the elucidation of pathological basis of the prescription-syndrome of Yi Guan Jian.

国家自然科学基金面上项目（81173223）：滋肾养肝方药调控胎肝干/祖细胞在硬化肝脏中的分化取向及其机制，负责人：慕永平；国家自然科学基金面上项目（81573948）：黄芪汤调控肝祖细胞NUMB/NOTCH信号通路抗胆汁性肝纤维化的机制研究，负责人：慕永平；国家自然科学基金面上项目（81273728）：基于Smad7蛋白表达调控解析黄芪总皂苷与甘草酸配伍抗肝纤维化的效应机制，负责人：刘平。