目的：探讨消痈溃得康及其拆方对水-束缚应激引起的大鼠胃黏膜损伤的保护作用及机制。方法：将大鼠随机平均分为正常组、模型组、消痈溃得康组、清热解毒组、和血止血组、托里生肌组。每天早晚两次灌胃，正常组和模型组给予等体积生理盐水，连续5 天，末次给药1h后造模。取大鼠血、胃，将胃拍照、分割。结果：水-束缚应激引起大鼠胃及血清中谷胱甘肽（Glutataione，GSH）含量降低、脂质过氧化物（Lipid Hydroperoxide，LPO）含量升高，谷胱甘肽过氧化物酶（Glutathione Peroxidase，GPX）、诱导型一氧化氮合酶（Inducible Nitric Oxide Synthase，iNOS）酶活力降低。消痈溃得康及各拆方均能够抑制水-束缚应激引起的大鼠胃黏膜损伤，提高水-束缚应激引起的大鼠胃组织及血清中GSH含量及GPX、iNOS酶活力；降低LPO含量。结论：消痈溃得康及其拆方对水-束缚应激引起的大鼠胃黏膜损伤起到保护，其中托里生肌组药物作用最明显，抗氧化作用可能是其重要的机制之一。

This ostudy aimed at exploring the effects and mechanisms of XYKDK and its dissected constituents on water immersion restraint stress-induced gastric mucosal injury in rats.Wistar rats were randomly divided into the following 6 groups:the normal group,the model group,XYKDK group,Qing Re Jie Du(QRJD)group,He Xue Zhi Xue(HXZX)group and Tuo Li Sheng Ji(TLSJ)group.The rats in the XYKDK, QRJD,HXZX and TLSJ groups were pretreated with their corresponding medicine,while the normal and model groups received equal administration with normal saline,twice a day,for 5 days;An hour after the final dosing,the rats were caused acute gastric mucosa injury.Six hours later,the stomachs of the rats were removed,photographed and cut.As a result,water immersion restraint stress caused gastric mucosa damage and reduced the content of glutataione(GSH)and the corresponding enzyme activity of glutataione peroxidase(GSH-PX),and inducible nitric oxide syntahse(iNOS),while increasing lipid hydroperoxide(LPO)content in gastric and serum.XYKDK and its dissected constituents all can alleviated water immersion restraint stress-induced gastric mucosal injury in rats,increased the content of GSH,decrease LPO,and improve GSH-PX and iNOS activity.In conclusion,XYKDK and its dissected constituents presented protective effects on water immersion restraint stress-induced gastric mucosal injury in rats.The medicine used in the TLSJ group showed marked effects,an antioxidant effect may be the mechanisms behind this.

国家自然科学基金委面上项目（81173380）：基于表观遗传学技术研究“以痈论治”胃溃疡的分子机制，负责人：才丽平；辽宁省教育厅高等学校优秀人才支持计划（LR2012032）：胃溃疡毒热病因及中药治疗分子机制研究，负责人：才丽平；沈阳市科技局重点实验室建设项目（F13-285-1-00）：沈阳市中医药重点实验室建设项目，负责人：才丽平。