[关键词]
[摘要]
目的:探讨原发性干燥综合征(Primary Sjogren's Syndrome,pSS)患者中医体质及证型分布特点。方法:收集60例pSS患者的一般资料,对其进行中医辨证分型和中医体质判定,并分析其分布特点。 结果:60例pSS患者中女性58例(96.67%),平均年龄52岁,平均病程63个月,常住地为新疆。首发临床症状最常见为口干、眼干、关节肿痛,少见皮肤黏膜和血液系统损害。以气阴两虚证(48.33%)最多,其次为湿热浸渍(26.67%)、脾气虚弱证(25.00%)。中医体质以阴虚质(58.33%)、阳虚质(58.33%)所占比例最大,其后分别为气郁质(48.33%)>气虚质(45.00%)>血瘀质(38.33%)>痰湿质(36.67%)>湿热质(18.33%)>特禀质(13.33%)>平和质(1.67%)。复发患者中未接受过pSS健康教育者达51.11%。结论:pSS患者中医体质有其独特的临床特点,阴虚质、阳虚质是其最常见的体制类型。中医证型以气阴两虚证最多。大部分复发患者未接受过pSS的健康教育。提示临床应根据pSS患者中医证型及中医体质特点,给予个性化治疗方案,同时加强pSS的健康管理,从而提高生存质量。
[Key word]
[Abstract]
This study aimed at exploring the features of the body constitution and syndrome types of TCM in patients with pSS.General information of 60 patients with pSS was collected.Their TCM syndrome types and TCM body constitution types were examed,while the distribution of pSS syndrome types in terms of their body constitution was analyzed. Among 60 pSS patients,58 of them(96.67%)were female with the average age of 52 years and an average course of 63 months.Their usual residence was Xinjiang.Their most common first symptoms included thirst,dry eyes and joint pain,and the damage of skin and mucous membranes and blood system was rare.It was found that the syndrome of both qi and yin deficiency was the most common(48.33%),followed by the impregnation syndrome of heat and dampness(26.67%)and the syndrome of the weakness of spleen qi(25%)in pSS patients.Yin deficiency(58.33%)and yang deficiency(58.33%)in the body constitution of TCM accounted for decent proportions,followed by the constitutions of qi stagnation(48.33%),qi deficiency(45.00%),blood stasis(38.33%),phlegm-dampness(36.67%),damp-heat(18.33%), allergic(13.33%)and yin-yang harmony(1.67%).Those without the health education of pSS accounted for 51.11% in cases of palindromia.In conclusion,yin deficiency and yang deficiency constitutions were most common,at most,the body constitution of both qi and yin deficiency,in pSS patients in accordance with TCM body constitution.Most pSS patients of palindromia didn’t received professional health education of pSS.All the causes above suggested that we should make individualized treatment programs according to clinical syndrome types and the characteristics of TCM body constitution in pSS patients for strengthening the health management of pSS and improving their quality of life.
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[基金项目]
新疆维吾尔自治区自然科学基金项目(2014211C021):新疆原发性干燥综合征气阴两虚证与miRNA-146a相关性研究,负责人:孙红艳;新疆医科大学科研创新基金项目(XYDCX201406):原发性干燥综合征患者血miRNA-146a水平与气阴两虚证的相关性分析,负责人:孙红艳。