目的：制备负电荷的姜黄素炎症靶向自微乳给药系统（NC-CUR-SMEDDS），并对其进行质量评价。方法：在前期姜黄素自微乳（CUR-SMEDDS）的研究基础上，以乳剂的粒径、Zeta电位、包封率和载药量为评价指标，通过单因素试验筛选电荷调节剂的最佳用量，制备NC-CUR-SMEDDS。通过观察微乳外观和微观形态并测定其粒径、Zeta电位、包封率及载药量对其进行质量评价。结果：当加入处方量4%的丁二酸二辛酯磺酸钠时，所形成的微乳Zeta电位可以达到-43.43±0.29mV，外观澄清、透明，粒径分布均匀，平均粒径为14.08±0.082nm，姜黄素载药量为26.48mg·g^-1，包封率为94.12%。结论：NC-CUR-SMEDDS包封率高，带负电，粒径分布均匀，符合结肠炎症靶向要求。

The aim of the study was to prepare and evaluate the quality of negatively charged selfmicroemulsifying drug delivery system of curcumin(NC-CUR-SMEDDS).Based on the CUR-SMEDDS,the optimum amount of excipients was confirmed by the single-factor design experiment taking mean particle size,Zeta potential,drug entrapment efficiency and the drug loadings of curcumin as the evaluation indices for the preparation of NC-CUR-SMEDDS.The quality of NC-CUR-SMEDDS was evaluated by observing its appearance status,transmission electron microscope micrographs and determining particle diameter,Zeta electric potential,drug entrapment efficiency and drug loading.As a result,it was found that the Zeta potential reached -43.43±0.29mV when 4% docusate sodium was added.The appearance of NC-CUR-SMEDDS remained clarified and transparent,and the microemulsion droplets appeared spherical without aggregation with uniform particle size distribution.The mean particle size was 14.08±0.082nm,the drug loading of curcumin was 26.48mg·g^-1 and the drug entrapment efficiency was 94.12%.It was concluded that NC-CUR-SMEDDS with high entrapment efficiency and uniform particle size distribution met the requirement of inflammatory target binding in the colon.

北京中医药大学自主选题项目（2016-JYB-XS072）：姜黄素炎症靶向自微乳治疗溃疡性结肠炎研究，负责人：刘乐环。