[关键词]
[摘要]
白藜芦醇是一种具有抗氧化、抗肿瘤、诱导细胞凋亡等生物活性的天然多酚类化合物。本文对近年来白藜芦醇诱导人宫颈癌HeLa细胞、白血病细胞、肝癌细胞和胃癌细胞等细胞凋亡方面的研究进展进行了分析和总结,并重点探讨了白藜芦醇诱导肿瘤细胞凋亡的分子机制,总结了白藜芦醇通过阻滞细胞周期、调节相关基因及蛋白表达和线粒体诱导细胞凋亡途径的研究现状,以及白藜芦醇作为肿瘤药物在临床研究中的潜在应用前景。
[Key word]
[Abstract]
Resveratrol is a natural polyphenolic substance with a variety of bioactivities,such as anti-oxidation,anti-tumor and apoptosis induction.This paper summarized the recent research progress of resveratrol induced cancerous cell apoptosis,including human cervical cancer HeLa cells,leukemia cells,hepatoma cells and gastric cancer cells,and analyzed the molecular mechanism behind resveratrol-induced cell apoptosis in tumor.In addition,resveratrol was investigated by blocking the cell cycle,regulating the expressions of related genes and proteins and mitochondria-induced apoptosis pathways as a potential application of cancer drugs to clinical researches.
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[基金项目]
河北省自然科学基金委面上项目(H2015201131):基于iNKT细胞类核苷免疫调节剂CH 干预型糖尿病的机制研究,负责人,陈冬志;河北省自然科学基金委面上项目(C2015201165):日本沼虾硫氰酸生成酶基因的免疫功能研究,负责人,谢松;河北大学医学学科专项资金建设项目(2012A2004):环境中铬对生殖细胞的毒性及微生物对其转化作用,负责人:李红权。