目的：在自血穴位注射疗法前期临床及基础研究的基础上，探讨其效应机制研究思路。方法：以"自血穴位注射"为检索词，检索Pubmed、CNKI、万方、维普等数据库1990-2017年文献，结合本课题组前期临床及实验研究，分析自血穴位注射疗法干预痤疮的效应机制。结果：自血穴位注射通过调节Th1/Th2免疫偏移与皮损局部微生态环境失衡发挥治疗寻常痤疮的作用，这可能是自血穴位注射治疗寻常痤疮的重要途径之一，也是其"调和阴阳，以平为期"作用的体现。结论：在今后的研究工作中，以自血穴位注射对Th1/Th2免疫偏移及皮损局部微生态失衡的影响为切入点，可为本法"调和阴阳，以平为期"的作用提供实验依据，为其临床应用提供一定的科学依据。

Based on previous clinical and basic research on autohemotherapy, its effective mechanism was explored."Autohemotherapy"was used as the keyword in the document retrieval of databases such as the Pubmed, CNKI,Wanfang, VIP, and etc. from 1990 to 2017. Previous clinical and basic research results of our team were also combined in the analysis of effective mechanism study on autohemotherapy in the treatment of acne. The results showed that autohemotherapy displayed the treatment effect of acne vulgaris through the regulation of Th1/Th2 immune deviation and micro ecological imbalance of local lesions, which may be one of the important ways in the treatment of acne vulgaris by autohemotherapy. It also reflected the regulation of Yin and Yang to reach the balance. It was concluded that in the future research, taking the effect of Th1/Th2 immune deviation and micro ecological imbalance of local lesions as the starting point, it will provide experimental basis for the effect of regulating Yin and Yang to reach the balance. It can provide certain scientific basis for its clinical application.

广东省中医药管理局面上项目（201701162）：基于Th1/Th2免疫偏移的自血穴位注射治疗痤疮的机制及量效时效规律研究，负责人：张东淑。南方医科大学科研启动计划项目（QD2016N004）：自血穴位注射对免疫抑制兔免疫功能、细胞因子作用机制及量效时效规律的研究，负责人：张东淑。