目的：优选余甘子总酚提取工艺，为其工业化生产提供数据参考。方法：以总酚、诃黎勒酸、没食子酸和粘酸-2-O-没食子酸酯提取量为综合评价指标，采用正交试验设计优选提取溶剂、溶剂用量、提取次数、提取时间等并进行验证，确定最佳提取工艺。结果：余甘子总酚提取工艺为10倍量70%乙醇提取3次，每次90min。结论：本文优化获得的余甘子总酚提取工艺稳定可靠，简便易行，为余甘子产业化研究提供依据。

This study was aimed to optimize the extraction method for total polyphenol from Phyllanthus emblica through multi-target orthogonal experiment, in order to provide data reference for its industrial production. The comprehensive evaluation indexes included the extraction yield, extraction percentage of total polyphenol, chebulagic acid, gallic acid, mucic acid-2-O-gallate, were verified. The ethanol concentration, solid-liquid ratio and extraction time were crucial indexes for orthogonal design. The results showed that the best extraction process was using 10 times dosage 70% ethanol, to extract the medical material three time, 90 minutes for every time. It was concluded that the extraction technology was reliable. This method was stable, quick and simple. It laid a fundamental foundation for the extraction method exploration.

国家自然科学基金面上项目（81274187）：基于藏药余甘子酚酸类成分体内动态变化的抗癌药效物质与质量控制研究，负责人：张兰珍。