中药材资源与质量是整个中医药产业链可持续发展的基础与保障。在决定中药材质量的诸多因素中，有效成分是其具有确切临床疗效的物质基础，药效物质的有无多寡是药材质量的核心要素。药效物质的积累水平与原植物的遗传背景密切相关，因此可通过阐明有效成分生源途径，揭示药材品质物质内涵形成机制，调控有效成分生物合成，实现药材品质保障与提升。基于药效物质的中药材品质调控技术体系包括整合分析高通量检测手段所获得的系统生物学多重组学数据，解析有效成分生源合成的遗传机制，从中挖掘和鉴定具品质识别功用的分子标记，将生源途径调控技术应用于中药材优异种质创制、种植过程精准管理和采收分拣质量识别的全程控制，实现有效成分高效合成和/或稳定积累，提升药材品质。

The resources and quality of Chinese herbal medicine is the foundation and guarantee for the sustainable development of the whole industry chain of traditional Chinese medicine. The effective component, having clinical curative effect, is the material base of Chinese herbal medicine, and is the core for the quality of medicinal material factors (quality). The accumulation of efficacy material is closely related to the genetic background of the original plant. By clarifying active ingredients biosynthesis, revealing medicinal material quality formation mechanism, regulating the content of effective components, the quality of medicine could be guarantee and ascend. The quality control technology based on active ingredients of Traditional Chinese medicine quality includes integrated analysis of high-throughput sequencing and systems biology data, revealing synthetic genetic mechanisms of active ingredients, excavating molecular markers of the quality, creating excellent germplasm, forming cultivation techniques, establishing classification standard of medicinal materials, and finally realizes the full industrial chain control of Chinese herbal medicine production. Taken all of these together could ensure the quality of medicinal materials.

国家自然科学基金委国家杰出青年科学基金项目（81325024）：中药药效物质，负责人：陈万生；国家自然科学基金面上项目（31670292）：茉莉 酸响应的AP2/ERF 转录因子对菘蓝木脂素生物合成的调控作用及其分子机制研究，负责人：张磊；国家自然科学基金面上项目( 81673529)： 青蒿MYB家族转录因子在青蒿素合成及腺毛发育中的调控机制研究，负责人：谭何新；国家自然科学基金面上项目（81673550）：丹参根系形 态、结构特征与有效成分积累的关联性及形成机制研究，负责人：陈军峰；国家自然科学基金面上项目（31770329）：丹酚酸B生物合成关键催 化酶丹参漆酶的发现与功能研究，负责人：李卿。