目的：观察不同脏腑虚损慢性阻塞性肺疾病稳定期患者骨骼肌含量及骨骼肌障碍的发生，探讨合适的中医治法以改善患者骨骼肌情况。方法：选择符合纳入条件的慢性阻塞性肺疾病稳定期患者140例，根据脏腑虚损情况分为肺气虚、肺脾气虚、肺肾气虚3种证型，通过人体成分分析测量其骨骼肌含量及体脂百分比，计算去脂肪指数，分析不同脏腑虚损类型与骨骼肌含量及发生骨骼肌功能障碍的关系。结果：3组慢阻肺稳定期患者均有不同程度的骨骼肌功能障碍，其中肺脾气虚组骨骼肌含量、双下肢肌肉量最低，更易合并骨骼肌功能障碍（P<0.05）。肺气虚组与肺肾气虚组之间上述指标无明显差异（P>0.05）。结论：肺脾气虚证的COPD患者可能更易发生骨骼肌含量减少，有易合并骨骼肌功能障碍趋势，运用补脾益气法可改善患者骨骼肌含量。

This study was aimed to observe the occurrence of skeletal muscle content and skeletal muscle disorders (SMD) in patients with chronic obstructive pulmonary disease (COPD) stabilization phase in different zang-fu deficiency, and to discuss the proper method of traditional Chinese medicine (TCM) to improve the condition of skeletal muscle. A total of 140 COPD patients in stabilization phase were selected and divided into 3 groups, which were Fei Qi-Xu (FQX), Fei-Pi Qi-Xu (FPQX), Fei-Shen Qi-Xu (FSQX) according to the zang-fu deficiency condition. Through the body composition analysis of measuring the content of skeletal muscle and body fat percentage, the fat index was calculated and different zang-fu deficiency types, content of skeletal muscle and the relationship between SMD occurrences were analyzed. The results showed that all patients with COPD in stabilization phase from three groups had different degrees of SMD. Among them, contents of skeletal muscle and muscle mass of both lower limbs of FPQX group were the lowest, which was easier to complicated with SMD (P<0.05). There was no significant difference on indexes mentioned above between the FQX and FSQX group (P>0.05). It was concluded that patients with COPD of FPQX type may be more likely to have reduced skeletal muscle content, and have a tendency to combine with SMD. Using Bu-Pi Yi-Qi (BPYQ) method may improve patient??s skeletal muscle content.

国家中医药管理局国家中医临床研究基地业务建设科研专项（JDZX2015232）：慢性阻塞性肺疾病患者发展“快”“慢”的差异蛋白质组学研究，负责人：李风森。