目的:基于含水量和单双酯型生物碱含量，探究栽培附子（江油附子）和野生附子（南阳附子）去皮的差异。方法：测定江油附子和张仲景使用的南阳附子去皮前后含水量，采用药典法测定附子去皮前后单双酯型生物碱的含量。结果：江油附子皮含水量显著高于南阳附子，南阳附子皮占整个附子的重量比例显著高于江油附子，江油附子去皮前含水量显著高于去皮后，南阳附子去皮后含水量显著高于去皮前。南阳附子皮单双酯型生物碱含量均显著高于江油附子。江油和南阳附子去皮前和去皮后单酯型生物碱含量均无显著差异，但江油附子双酯型生物碱含量去皮前显著高于去皮后，南阳附子双酯型生物碱含量去皮前显著低于去皮后。结论：江油附子去皮原因可能与附子皮中含有较高的双酯型生物碱和含水量有关，张仲景使用南阳附子去皮可能与其占比高，含有较高的双酯型生物碱，去皮后能降低毒性且便于生物碱溶出有关。

Based on the content of water and the content of single and diester alkaloids, the difference of peeling between cultivated radix aconiti carmichaeli (radix aconiti carmichaeli in Jiangyou) and wild radix aconiti carmichaeli (radix aconiti carmichaeli in Nanyang) was studied. Water contents of radix aconiti carmichaeli in Jiangyou and Zhang Zhongjing used Nanyang radix aconiti lateralis were determined before and after peeling. Contents of single and diester alkaloids were determined by the pharmacopoeia method before and after the peeling of radix aconiti carmichaeli in Nanyang. The results showed that Jiangyou radix aconiti carmichaeli skin moisture was significantly higher than that of Nanyang radix aconiti carmichaeli, the total weight ratio of Nanyang peeling of radix aconiti carmichaeli was significantly higher than that of Jiangyou. Radix aconiti carmichaeli peeled before water content was significantly higher than after peeled. Nanyang radix aconiti carmichaeli peeled water content was significantly higher than before peeling. Contents of single and diester alkaloids in Nanyang radix aconiti carmichaeli were significantly higher than those in Jiangyou radix aconiti carmichaeli. There was no significant difference on the content of single alkaloids between Jiangyou and Nanyang before and after peeling. Diester alkaloids in Nanyang radix aconiti carmichaeli were significantly lower before peeling than those after peeling. It was concluded that the reason for peeling in Jiangyou radix aconiti carmichaeli may be the high content of diester alkaloids and water in the skin. Zhang Zhongjing peeled the skin when using Nanyang radix aconiti carmichaeli may be due to its high proportion of radix aconiti carmichaeli peel and high diester alkaloids containing. After peeling, it can reduce toxicity and make the dissolution of alkaloids easy.

北京市自然科学基金委中药炮制基础研究项目（7162120):基于物质基础的张仲景经方中附子炮制及应用的科学内涵研究，负责人：李飞。