目的：优选娑罗子罐组分级逆流提取技术最佳工艺。方法：应用罐组分级逆流提取装置，选用3个 单元组数，采用L9（34）正交试验，以七叶皂苷A+B转移率、干膏得率为考察指标，考察料液比、乙醇浓度、提取时 间、提取温度4个因素，优选最佳工艺；并与传统热回流提取方法进行比较。结果：最佳提取工艺为料液比1: 10，乙醇浓度70%，阶段提取时间20 min，提取温度60℃。结论：优选得到的最佳工艺具有提取率高、能耗低等 优点，为娑罗子提取工艺改造升级提供依据。

This study was aimed to optimize the extraction process of Aesculi. The extraction process of Aesculi was optimized through orthogonal experiment while the transfer rate of escin Ia and escin Ib. And the yield of dry extract. was adopted as marks. And ratio of solid to liquid, the ethanol concentration , extraction time and extraction temperature were studies. The results showed that optimized extraction conditions of Aesculi were determined as follows. The ratio of solid to liquid was 1: 10, the ethanol concentration was 70% , extracted for 20 minutes ever stage and the extraction temperature was 60℃ . It was concluded that the extraction process is efficacious for general flavone and icariin extraction. The method is suitable for the standardized production technology of Aesculi.

科学技术部国家重点研发计划项目(2017YFC1701002)：娑罗子规模化种植及精准扶贫示范研究，负责人：石召华；科学技术部国家“十二五”重 大新药创制科技重大专项资助项目(2014ZX09201-022-03)：中药注射剂大品种七叶皂苷冻干粉针技术改造及其全程质量控制体系的建立，负 责人：石召华。